The stochastic gradient descent algorithm for training neural networks is widely used in many machine learning, especially deep learning tasks. The stochastic gradient descent algorithm operates by choosing a small fraction ...

Pdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β-cell function. However, little is known regarding its role in mature β-cells or the positive- and negative-acting coregulators ...

Mechanochemical methods of synthesis (specifically grinding and milling) have not yet been widely used by organometallic chemists. This thesis surveys recent developments in the field, outlining differences that can occur ...

Several viruses are known to induce stress granules (SGs), however, a role for these structures during viral infection remains unknown. We first showed that respiratory syncytial virus (RSV) induces SGs starting approximately ...

Malaria is an entirely preventable and treatable disease, yet it is endemic in nearly half of the countries around the world. One of the most important drug targets for this disease is the hemozoin formation pathway, a ...

This work describes three separate projects, for which Density Functional Theory (DFT) computations provide a unifying theme. The DFT approach gives a theoretically sound way to model the chemical and physical properties ...

Polyunsaturated fatty acids can be liberated from phospholipids in the membrane bilayer and enzymatically converted to oxygenated bioactive lipid compounds that contribute to the pathology, or in some cases, the resolution ...

Deficits in social interaction (SI) are a core symptom of Autism Spectrum Disorders (ASD), however treatments for social deficits are notably lacking. Elucidating brain circuits and neuromodulatory signaling systems that ...

For the past decade science education has increasingly advocated for student participation in the practice of science. However, current representations of scientific practice often under-represent and under-theorize the ...

Head Start is a comprehensive, early childhood development program designed to augment the human capital and health capital levels of disadvantaged children. Grossman's (1972) health capital model suggests that early ...