Browsing by Author "Brian O. Bachmann"
Now showing items 21-40 of 44
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Kramer, Glenna Jean (2014-10-06)Department: ChemistryK-26 and related (R)-AHEP containing natural products have been described as some of the most potent natural product inhibitors of human angiotensin-I converting enzyme (ACE) a physiologically important enzyme central to ...
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Chau, Stephen Thomas (2011-09-20)Department: ChemistryThe dissertation contained herein describes the synthetic efforts towards the total synthesis of the cytotoxic macrolide ammocidin D. Ammocidin D, isolated by Hayakawa and coworkers in 2009 from the culture broth of ...
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Romaine, Ian Matthew (2010-12-20)Department: ChemistryIn 1998, Hori and coworkers1 reported a small group of pseudodimeric aromatic polyketides, named hibarimicins, which are produced by Microbispora sp found in a soil sample. This group consisted of more than ten components. ...
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Aldrich, Leslie Nichole (2012-07-23)Department: ChemistryProgress toward the total synthesis of marineosins A and B, prodigiosin-like alkaloids with novel spiroiminal centers, is described. The synthesis of the proposed biosynthetic precursor was completed and the viability of ...
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Wenzler, Marta Elise (2015-12-22)Department: ChemistryUpenamide is a marine alkaloid natural product isolated in 2000 from the marine sponge Echinochalina sp. Protolithospongia. Spectral analysis of the marine alkaloid by the Scheuer group determined the structure upenamide ...
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Mathew, Priya Ann (2012-07-27)Department: ChemistryMitomycin C is a clinically used antitumor natural product isolated from <i>Streptomyces caespitosus</i>. The biological activity and synthetic challenge of mitomycin C has generated broad interest in its chemical synthesis. ...
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Hardesty, William Michael (2011-01-12)Department: ChemistryCHEMISTRY PROTEOMIC ANALYSIS AND CLASSIFICATION OF METASTATIC MELANOMA BY MALDI IMAGING MASS SPECTROMETRY WILLIAM MICHAEL HARDESTY Dissertation under the direction of Professor Richard M. Caprioli Classification of ...
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Chacon, Almary (2007-12-13)Department: ChemistryProtein identification generally involves enzymatic digestion of proteins followed by mass spectrometry (MS) sequencing analysis of the resulting peptides, a process referred to as bottom-up proteomics. Another approach ...
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Batiste, Suzanne Marie (2018-03-28)Department: ChemistryFungal cyclooligomeric depsipeptides (CODs) are structurally privileged natural products as demonstrated by their broad spectrum of biological activities, including antibiotic, insecticidal, and antitumor activities. In ...
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Stow, Sarah Markley (2015-05-22)Department: ChemistryStructural ion mobility-mass spectrometry (IM-MS) is often paired with computational conformational space studies to provide more insight into the experimental measurements. From the IM-MS or gas phase electrophoresis ...
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Enders, Jeffrey Richard (2012-12-17)Department: ChemistrySystems biology seeks to describe the function of a biological system using a holistic, multiscale approach. This approach encompasses the analyses of molecular classes such as the genome, transcriptome, proteome, and ...
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Brown, Kyle Lamar (2008-06-06)Department: ChemistryThis dissertation involves the structural and equilibrium studies of three DNA lesions: aflatoxin B1 formamidopyrimidine, methyl formamidopyrimidine, and thymine glycol. Studies of the methyl formamidopyrimidine ...
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Lamberson, Connor Reid (2017-05-26)Department: ChemistryLipids are loosely defined as a group of naturally occurring organic compounds which are hydrophobic or amphipathic in nature, but which are also readily soluble in organic solvents. These solubility features are present ...
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Bai, Mingfeng (2007-09-07)Department: ChemistryThe ultimate success of molecular imaging depends heavily upon discovery of selective imaging probes. This dissertation is focused on development, characterization and in vitro/in vivo imaging of novel imaging agents that ...
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Tang, Dewei (2013-04-15)Department: Chemical and Physical BiologyThis project is focused on PET probe development for cancer imaging by targeting a potential cancer biomarker- Translocator Protein (TSPO). In this project, I evaluated 18F-DPA-714, a pyrazolopyrimindine probe, as a TSPO ...
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Metts, Adam Mason (2019-03-27)Department: ChemistryThe cell is regulated by a vast network of dynamic protein interactions that facilitate various sub-cellular functions. To systematically monitor and characterize these transient and rapidly changing protein interactions, ...
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Doody, Amanda Blane (2014-03-21)Department: ChemistryFeglymycin is a tridecapeptide that has been shown to act as an inhibitor of the formation of HIV syncytia as well as the cell-to-cell transmission of the virus. The natural product contains thirteen amino acid residues, ...
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Wang, Jingqi (2009-10-20)Department: ChemistryAs a selective apoptosis inducer, apoptolidin A was isolated from Nocardiopsis Sp. by Japanese chemists in 1997. Khosla and coworkers have demonstrated that apoptolidin A could inhibit the activity of mitochondrial F0F1-ATP ...
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Reniere, Michelle Lynne (2010-04-12)Department: Microbiology and ImmunologyStaphylococcus aureus is an important human pathogen and its ability to cause disease is absolutely dependent on iron acquisition from the host. S. aureus obtains iron during infection from vertebrate hemoglobin via the ...
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Brogan, John Trevor (2013-07-29)Department: Chemical and Physical BiologyThe first total synthesis of (+)-7-bromotrypargine, a β-carboline alkaloid from Ancornia sp. was completed in 9 steps, 8 steps longest linear sequence, and 40% overall yield. Biological characterization found that ...