Browsing by Department "Biochemistry"
Now showing items 21-40 of 124
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(2011-04-16)Department: BiochemistryDETERMINANTS OF CYCLOOXYGENASE-2-MEDIATED OXIDATIVE METABOLISM OF THE ENDOCANNABINOID, 2-ARACHIDONOYL GLYCEROL, IN VITRO AND EX VIVO Joel Musee Dissertation under the direction of Professor Lawrence J. Marnett PGHSs ...
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(2022-06-13)Department: BiochemistryAlzheimer’s disease (AD) is the most common form of dementia in the U.S. with no disease-modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and plaques, which have long been thought to ...
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(2017-08-03)Department: BiochemistryDespite significant progress in breast cancer therapeutics and survival in recent decades, treatment of triple-negative breast cancer (TNBC) has lagged behind in these advances, with cytotoxic chemotherapy remaining the ...
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(2009-06-08)Department: Biochemistryp73, a transcription factor that plays essential roles during development and tumor suppression, shares significant sequence identity with p53. However, p53 and p73 are regulated by different pathways, and p73 is not ...
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(2015-04-20)Department: BiochemistryRas is a small GTPase that functions as a molecular switch, cycling between inactive (GDP-bound) and active (GTP-bound) states. Mutations in Ras fix the protein in the active state and endow tumor cells with the ability ...
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(2019-03-15)Department: BiochemistryCTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite ...
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(2005-11-02)Department: BiochemistryTopoisomerase II is an essential enzyme that controls DNA topology. This enzyme generates a protein-linked DNA break as a catalytic intermediate. This intermediate, known as the cleavage complex, is present in very low ...
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(2010-04-30)Department: BiochemistryDiepoxybutane is a mutagenic and carcinogenic oxidation product of the important industrial chemical and environmental contaminant butadiene. The mutagenic potential of diepoxybutane is thought to be due in part to its ...
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(2010-08-03)Department: BiochemistryReplication Protein A (RPA) is the primary eukaryotic ssDNA binding protein utilized in preventing secondary structure formation and re-annealing of unwound DNA strands, thereby controlling access to DNA templates in diverse ...
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(2016-04-06)Department: BiochemistryApoptosis signal-regulating kinase 1 (ASK1) is a critical sensor of cellular stress that is capable of integrating several chemically distinct signals into a single response pathway and is believed to play a role in several ...
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(2006-06-30)Department: BiochemistryThis project involved the investigation of both the dynamic features of the dimer interface of the Mu class GSH transferase rGSTM1-1, as well as, the structural and mechanistic characteristics of HCCA Isomerase, an enzyme ...
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Early Events in RNA Virus Infection: Profiling the Pre-Replicated Interactome of Chikungunya Virus (2020-11-05)Department: BiochemistryThe race between RNA virus replication and the host innate immune response begins immediately after viral infection. While awaiting transcriptional upregulation of interferons and antiviral genes, cells must rely on mRNAs ...
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Effects of DNA Geometry and Topoisomerase II Poisons on Human and Bacterial Type II Topoisomerases (2017-03-15)Department: BiochemistryThe topological state of DNA has a dramatic effect on nucleic acid processes in cells. Type II topoisomerases are necessary enzymes that help regulate the topological state of the genome, but their activity requires the ...
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(2016-04-05)Department: BiochemistryTopoisomerase II plays many essential roles in genome maintenance. To carry out its physiological functions, the enzyme generates transient double-stranded breaks in the DNA to help resolve topological problems that occur ...
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(2021-05-10)Department: BiochemistryUpon pathogen detection, the innate immune system triggers signaling events leading to upregulation of pro-inflammatory and anti-microbial mRNA transcripts. RNA-binding proteins (RBPs) interact with these critical mRNAs ...
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(2013-04-09)Department: BiochemistryGiven the fundamental roles of histone deacetylases (HDACs) in the regulation of DNA repair, replication, transcription and chromatin structure, it is fitting that therapies targeting HDAC activities are now being explored ...
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(2020-06-11)Department: BiochemistryCurrent models of enhancer dynamics only weakly describe a role for DNA methylation within the ordered process of cellular differentiation and enhancer activation, both frequently perturbed in human disease. However, DNA ...
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(2018-11-21)Department: BiochemistryThe ATR kinase controls cell cycle transitions and the DNA damage response. Budding yeast contain three activators of Mec1ATR; however, only TOPBP1 is known to activate ATR in vertebrates. We identified ETAA1 as a replication ...
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(2021-10-18)Department: Biochemistryp53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. ...
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(2020-03-30)Department: BiochemistryThe dorsal root ganglia (DRG) house the primary afferent neurons responsible for somatosensation, including pain. We previously identified Jedi-1 (PEAR1/MEGF12) as a phagocytic receptor expressed by satellite glia in the ...