Browsing by Subject "breast cancer"
Now showing items 21-40 of 54
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(2010-04-12)Department: Biomedical EngineeringImaging protocols for detection of breast cancer metastases to bone in clinical imaging have long been standardized, but to date small animal imaging still uses a variety of imaging modalities and protocols. Although imaging ...
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(2017-04-17)Department: Biomedical InformaticsPatient care is complex and imperfect. Understanding and improving patient care requires clinical datasets and scientific methodology. We designed a set of methods to characterize the state of patient care and identify ...
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(2019-03-29)Department: Cancer BiologyDespite the high prevalence of breast cancer metastasis to bone, there are currently no therapeutic options to cure metastatic disease. This deficit is in part due to the lack in vivo models that recapitulate prolonged ...
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(2017-12-11)Department: SociologyThis dissertation uses a qualitative approach to study this important topic in the area of intersectionality and health. My primary data are semi-structured interviews I conducted with 49 black breast cancer survivors in ...
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(2024-03-21)Department: Biomedical EngineeringBreast conserving surgery (BCS) is a common procedure for early-stage breast cancer where the tumor is removed with a surrounding margin of healthy tissue. BCS aims to excise breast tumors while preserving cosmesis, but ...
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(2014-11-26)Department: BiochemistryGenomic instability and deregulated proliferation are hallmarks of human tumors. Cytotoxic chemotherapeutics, including cisplatin, have been used for over forty years to combat cancers that have deregulated proliferation ...
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(2011-08-30)Department: Cancer BiologyBreast cancer frequently metastasizes to the skeleton with severe consequence to patient quality of life. Patients who develop bone metastases suffer from severe bone pain and increased risk of developing hypercalcemia ...
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(2024-03-26)Department: Cancer BiologyAlthough immune checkpoint inhibition (ICI) has proven successful in treating cancer, patients with triple-negative breast cancer (TNBC) often develop therapy resistance, and the underlying mechanisms remain unclear. MHC-I ...
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(2012-04-09)Department: Biomedical EngineeringThe optical redox ratio (fluorescence intensity of NADH divided by that of FAD), was acquired for a panel of breast cancer cell lines to investigate how overexpression of human epidermal growth factor receptor 2 (HER2) ...
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Optical spectroscopy for the evaluation of surgical margin status following breast cancer resection (2009-12-23)Department: Biomedical EngineeringThe presence of tumor within 1-2 millimeters of the surgical margin following partial mastectomies is strongly correlated with the risk of local breast tumor recurrence; thus, there is a need to develop a non-invasive, ...
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(Medicine, 2019-06)Higher trait optimism and/or lower cynical hostility are associated with healthier behaviors and lower risk of morbidity and mortality, yet their association with health care utilization has been understudied. Whether these ...
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(2017-05-30)Department: Biomedical InformaticsPathway exploration can support clinical research efforts and shared decision making between providers, patients, and their families. In this work, we extend the Pathfinder temporal abstraction method and developed a ...
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(2019-10-29)Department: PathologyHeterogeneity in estrogen receptor positive breast cancers is poorly understood. Copy number alterations and structural differences contribute to carcinogenesis. Current cell line genomes representing the histological ...
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(2007-05-30)Department: PsychologyMothers and their adolescent and young adult daughters at risk for breast cancer may experience stress as a result of being at risk for the disease. The current study examined psychological and biological stress responses ...
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(2010-12-10)Department: Cancer BiologyOverexpression of activated oncogenes such as Ras(V12) in primary cells induces senescence rather than transformation, thus suppressing tumorigenesis. C/EBPbeta is required for Ras(V12)-induced senescence in mouse embryonic ...
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(2008-03-06)Department: Cancer BiologyChemokines are a family of small chemotactic cytokines that bind seven transmembrane G protein-coupled receptors. Roles for CXC chemokines and the receptors CXCR2 and CXCR4 in inflammation-mediated tumorigenesis, angiogenesis, ...
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(2012-07-26)Department: Cancer BiologyTransforming growth factor-beta (TGF-β) has a dual role during tumor progression initially as a suppressor and then as a promoter. Much is known about the contribution of TGF-β signaling to tumorigenesis, yet, the role ...
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(2015-03-18)Department: Cancer BiologyCANCER BIOLOGY Roles of Fibroblast MMP2 in Breast to Lung Metastasis Andreia L. Bates Dissertation under the direction of Barbara Fingleton, PhD Breast cancer five-year survival rates decrease from 99% for patients ...
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(2011-12-12)Department: PathologyIn this dissertation, I examined the function of the alpha2beta1 integrin in epithelial tumor cells as well as in the tumor microenvironment. The alpha2beta1 integrin is a surface heterodimeric receptor found on epithelial, ...
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(2018-04-11)Department: PathologyThe family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...