Browsing by Subject "diabetes"
Now showing items 21-38 of 38
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(2013-05-28)Department: Molecular Physiology and BiophysicsThis project investigated the significance of extramyocellular barriers to the pathogenesis of skeletal muscle insulin resistance and their potential as therapeutic targets. The goals of this dissertation were to determine ...
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(2006-04-12)Department: BiochemistryNon-enzymatic modification by glucose of proteins induces protein damage through the formation of advanced glycation end products (AGEs). AGEs have been implicated in the pathogenesis of a number of diseases including ...
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(2016-11-22)Department: Interdisciplinary Studies: Metabolic PharmacologyType 2 diabetes affects 10% of the United States population, and patients with diabetes have an increased risk for diseases such as atherosclerosis and hypertension. Since all these diseases are associated with insulin ...
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(2021-06-24)Department: Cell & Developmental BiologyTo better understand how Insm1, Neurod1 and Pax6 contribute to the formation and function of pancreatic endocrine cells I performed comparative immunohistochemical, transcriptomic, functional enrichment, and RNA splicing ...
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(2012-11-21)Department: PharmacologyProstaglandin E2 (PGE2) is a lipid autacoid, which is an oxidative metabolite of arachidonic acid synthesized by cyclooxygenase and prostaglandin E synthases. PGE2 is proposed to mediate in part the pathophysiology of ...
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(2017-03-31)Department: Cell and Developmental BiologyBoth type I and type II diabetes are related to β-cell defects in the pancreatic islet of Langerhans. Deriving β-cells from stem cells and other mature cell types provides an important cell source for transplantation-based ...
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(2013-04-11)Department: Molecular Physiology and BiophysicsObesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
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(2017-12-12)Department: Molecular Physiology and BiophysicsObesity has reached epidemic proportions worldwide, with some of the greatest severity in the United States. The most recent data reports ~70% of the American population is overweight (BMI ≥ 25 kg/m2) and ~35% obese (BMI ...
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(2018-10-31)Department: Molecular Physiology and BiophysicsmicroRNAs (miRNA) have been shown to be critical players in metabolism. While most miRNAs studies have focused on their functional role within cells, miRNAs are also found extracellularly and have been proposed to participate ...
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(2005-04-19)Department: PsychologyThe goal of this study was to examine the relationship between diabetes and depressive symptoms in the Southern Community Cohort Study (SCCS). The SCCS is a prospective, community-based cohort study examining racial ...
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(2008-09-29)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS REGENERATION AND EXPANSION AMANDA ACKERMANN MISFELDT Dissertation under the direction of Maureen Gannon, Ph.D. The size of an organism’s ...
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(2010-07-15)Department: NeuroscienceMonoamine signaling in the central nervous system plays an essential role in circuits involving attention, mood, memory, and stress as well as providing pivotal support for autonomic function in the peripheral nervous ...
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(2009-12-11)Department: Molecular Physiology and BiophysicsObesity is a strong risk factor for type 2 diabetes and cardiovascular disease partly because of the changes that occur in white adipose tissue (WAT) during weight gain. As obesity progresses, WAT expands, becomes ...
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(2014-07-22)Department: EpidemiologyEPIDEMIOLOGY The Role of Physical Activity and Obesity in the Occurrence of Major Cardiovascular Events and Mortality among a Low-Income Population with Diabetes Kimberly R. Glenn Dissertation under the direction of Professor ...
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The Role of the Prostaglandin E2 EP3 Receptor in Obesity, Insulin Resistance, and Glycemic Control (2015-12-01)Department: PharmacologyMice carrying a targeted disruption of the prostaglandin E2 E-prostanoid receptor 3 (EP3) gene, Ptger3, were fed a high-fat diet (HFD), or a micronutrient matched control diet, to investigate the effects of disrupted ...
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(2006-12-04)Department: Cell and Development BiologyThe transcription factor Pancreatic and duodenal homeobox 1 (Pdx1) is essential for formation of the pancreas and for glucose-responsive insulin secretion from mature pancreatic beta cells. In humans and mice, heterozygosity ...
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(2011-12-04)Department: Molecular Physiology and BiophysicsPluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...
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(2017-02-24)Department: Cell and Developmental BiologyReprogramming of pancreatic cells into new beta-like cells is a potential therapy for Type 1 diabetes. Pancreatic acinar cells are an appealing target for cellular reprogramming since they are abundant, derived from a ...