Browsing by Title
Now showing items 5995-6014 of 17442
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(2006-10-06)Department: Molecular BiologyThis project was concerned with the functional components of mammalian DNA replication origins and how the misuse of a start site for DNA replication at the FMR1 locus might contribute to human Fragile X Syndrome. In ...
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(2017-11-28)Department: Biomedical EngineeringThe identification of patterns of highly correlated low frequency Magnetic Resonance Imaging (MRI) signals in resting states provides a powerful approach to assess brain functional organization. However, functional MRI ...
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(2008-04-04)Department: Biological SciencesHuman replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in DNA metabolism. RPA binds ssDNA transiently during initiation of DNA replication. When this dissertation research began, the ...
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(2013-04-18)Department: PsychologyIt has long been recognized that people demonstrate orienting responses to novel, salient stimuli in the environment. The presentation of such an oddball stimulus does not only induce physiological, reflexive responses, ...
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(2016-11-17)Department: BiochemistryOxidative stress is a contributing factor in a number of chronic diseases, including cancer, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation that occurs during periods of oxidative stress and decomposition ...
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(2020-08-20)Department: Electrical EngineeringFunctional magnetic resonance imaging (fMRI) is widely used to study the characteristics of the human brain activities. Most of the analysis methods are based on voxels. Some summary statistics characterizing the temporal ...
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(2022-06-28)Department: PsychologyWhen brain networks deviate from typical development, it is thought to contribute to varying forms of psychopathology. However, research has been limited by the reliance on discrete diagnostic categories that overlook the ...
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(2004-04-05)Department: PsychologyConsiderable debate exists over how the cortex is able to represent an accurate, detailed map of visual space while simultaneously allowing different cells to be organized to analyze different stimulus attributes. A ...
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(2020-01-01)Introduction: Targeted temperature management (TTM) after out-of-hospital cardiac arrest (OHCA) has been recommended in international guidelines since 2005. The TTM-trial published in 2013 showed no difference in survival ...
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(2021-03-22)Department: PharmacologyRegulated exocytosis is the process that directs the release of neurotransmitters and peptide hormones from neurons and endocrine cells. CAPS1, calcium-dependent activator protein for secretion 1, is a SNARE accessory ...
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(2011-01-27)Department: PsychologyFunctional reorganization of primary sensory cortex following peripheral sensory deprivation and other atypical sensory experience typically focused on changes in single neuron deficits till date. This dissertation studies ...
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(2009-04-21)Department: Cancer BiologyFUNCTIONAL STUDIES ON INTERLEUKIN 24 IN VITRO AND IN VIVO MIAO HE Thesis under the direction of Professor Peng Liang Among IL-20 family of cytokines, IL-19, IL-20 and IL-24 can each activate IL20R1/IL-20R2 heterodimeric ...
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(2013-07-29)Department: Biological SciencesThe social amoeba Dictyostelium discoideum senses the bacterial metabolite folic acid to track down bacteria. Previous studies suggested that the folic acid receptor is a serpentine receptor. In this study, I examined the ...
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(2019-01-15)Department: Civil EngineeringWith the ability to shorten production times, while simultaneously minimizing material waste, additive manufacturing technologies and techniques, including 3D printing, have emerged with the potential to revolutionize the ...
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(2018-07-10)Department: Microbiology and ImmunologyViral nonstructural proteins, which are not packaged into virions, are essential for the replication of most viruses. Reovirus, a nonenveloped, double-stranded RNA (dsRNA) virus, encodes three nonstructural proteins that ...
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(2018-08-22)Department: Microbiology and ImmunologyViral encephalitis is a serious and life-threatening inflammation of the central nervous system (CNS). However, mechanisms of viral neuroinvasion and disease pathogenesis in the CNS are often poorly understood. Mammalian ...
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(2020-08-25)Department: MathematicsThe calculation of fundamental group of II1 factors is one of the most important problems in the theory of von Neumann algebras. Motivated by his study of II1 factors arising from i.c.c. property (T) groups, A. Connes ...
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(2008-12-30)Department: Mechanical EngineeringThis thesis evaluates the fundamental understanding of electroosmotic flow in a heterogeneous converging-diverging circular microchannel. Three converging-diverging circular microchannels were modeled and the Poisson-Boltzmann ...
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(2018-03-15)
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(2022-03-29)Department: Biological SciencesDeep genome sequencing of the fungal kingdom, an ancient and diverse eukaryotic lineage, has shed light on the dynamics of genome evolution. For example, these studies have underscored the importance of evolution by gene ...