Browsing by Title
Now showing items 1572-1591 of 17454
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(2010-12-13)Department: Molecular Physiology and BiophysicsThe goal of my dissertation project was to characterize interactions between the transactivator Rap1 and Taf subunits of the TFIID complex. This experimental problem falls under a larger umbrella of gene regulation, since ...
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(2010-10-29)Department: BiochemistryThe mechanism controlling the switch between gene activation and repression is critically important for understanding the process of transcriptional regulation. Gene expression is highly controlled through a dynamic exchange ...
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(2012-03-28)Department: BiochemistrySimian Virus 40 uses its Large T antigen protein to bind and inactivate retinoblastoma tumor suppressor proteins, yielding cell transformation. T antigen is a modular protein with four domains connected by linkers. The ...
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(2008-07-28)Department: BiochemistryThe replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
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(2015-01-16)Department: PharmacologyPhospholipase D (PLD) is a ubiquitous enzyme found in prokaryotic and eukaryotic organisms that generates phosphatidic acid. A number of human bacterial pathogens produce PLD as virulence factors to promote infections. ...
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(2019-03-25)Department: Chemical and Physical BiologyCells constantly sense and respond to cues via signaling networks. These networks operate in dynamic systems and often serve multiple purposes, translating multiple inputs into multiple outputs depending on context. Because ...
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(2021-06-16)Department: Biological SciencesDNA damage within a cell can cause genome instability if not properly corrected. Endogenous factors including reactive metabolites and oxidative stress cause DNA damage in the form of modified DNA nucleobases. Base excision ...
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(2010-05-21)Department: Chemical EngineeringInfection is a common complication in open fractures that compromises bone healing. Currently, the clinical standard care for treating contaminated open fractures comprises a staged approach, wherein the wound is first ...
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(University of Colorado Law Review, 1995)This article offers an early examination of the law and governance of biodiversity (circa 1995) through the lenses of the Endangered Species Act, Clean Water Act, and Coastal Zone Management. It suggests that true multi-scalar, ...
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(2012-12-03)Department: Biomedical EngineeringMacrophages have been proposed as a potential therapeutic target because of their central role in the progression of a number of debilitating diseases, such as cancer and cardiovascular diseases. However, macrophages are ...
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(2014-07-02)Department: Biological SciencesMany eukaryotes use the ribonucleoprotein telomerase to replenish telomeric sequences lost during conventional DNA replication. In Saccharomyces cerevisiae, telomerase contains the catalytic reverse transcriptase, Est2p, ...
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(Wiley & Putnam, 1846)
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(American Schools of Oriental Research, 1973-04)
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(2018-11-13)Department: ReligionOne question guides this dissertation: what is a text? Answering this question pushes the boundaries of biblical studies, prompting more considerations: is a text limited to the words written on pages and inscribed in ...
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(Vanderbilt University. Blair School of Music, 2012-11-08)
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(2014-03-21)Department: ChemistryOver the course of billions of years, nature has developed incredible materials on the nanoscale for the efficient conversion of solar energy into chemical energy. One of these materials, Photosystem I (PSI), functions as ...
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(2009-08-11)Department: ChemistryThe use of fluorescent microscopy as a tool for studying biological systems has exploded with the development of the laser scanning confocal microscope. In conjunction with traditional biochemical techniques, it can plan ...
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(2010-04-12)Department: Cell and Developmental BiologyColorectal cancer is the second most lethal, non-cutaneous epithelial cancer in the United States. Metastasis contributes to the majority of cancer-related deaths in this disease. Metastasis closely resembles the ...
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(2005-02-03)Department: Biomedical EngineeringCell encapsulation is a novel therapeutic approach for the treatment of Type I Diabetes Mellitus that circumvents both the immunosuppression and limited allograft donor source dilemma. Current methods for scoring the ...
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(2023-11-17)Department: Molecular Pathology & ImmunologyGenomic and transcriptomic analysis have revolutionized our understanding of many cancers. However, genomic understanding of thyroid cancer has lagged behind other tumors; currently, thyroid cancer management is largely ...