Browsing by Title
Now showing items 3639-3658 of 17439
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(2022-06-13)Department: BiochemistryAlzheimer’s disease (AD) is the most common form of dementia in the U.S. with no disease-modifying therapies. A key hallmark of AD is the generation of amyloid-β (Aβ) peptides and plaques, which have long been thought to ...
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(2022-03-24)Department: Microbe-Host InteractionsExisting viral pathogens like human immunodeficiency virus (HIV), influenza virus, and coronaviruses, along with emerging infectious diseases, are constant worldwide threats, causing illness and death for millions of people ...
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(2013-06-18)Department: ChemistryThis project reports the synthesis of several dendritic polymers towards applications in intracellular transport. The structures discussed feature variations in core, periphery, and branched units all of which are manipulated ...
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(2021-06-13)Department: ChemistryThe development and application of multianalyte electrochemical biosensors to detect metabolites is vital for understanding the cellular processes and mechanisms of toxicity in model organ systems. The need to accurately ...
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(2021-03-24)Department: ChemistryNeurotransmitters are an extensive group of chemical messengers essential to the proper function of both physiological and psychological processes in humans. The comprehensive electrochemical detection of these compounds ...
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(2016-11-18)Department: ChemistryLigand-based computational drug discovery (LB-CADD) methods have been used widely over the last several decades to aid medicinal chemistry campaigns via virtual high-throughput screening (vHTS) and de-novo molecular design. ...
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(2019-06-27)Department: Microbiology and ImmunologyRecent advances in computational biology and sequencing technologies have led to the development of assays that generate a large number of measurements on a large number of samples (individuals or single cells). Experimental ...
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(2007-12-07)Department: Chemical EngineeringDEVELOPMENT AND APPLICATIONS OF A HETERO-BASED STATISTICAL ASSOCIATING FLUID THEORY <P> YUN PENG <P> Dissertation under the direction of Professor Clare McCabe <P> Understanding the thermodynamic properties of chemical ...
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(2016-04-18)Department: Electrical EngineeringLower-limb weakness or paralysis is a common impairment following stroke. In recent years numerous robotic-assisted systems have been developed to aid in post-stroke gait rehabilitation. The controllers developed for these ...
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(2023-11-02)Department: Mechanical EngineeringOne of the major goals for individuals with lower-limb loss is retaining their mobility and independence to stay engaged in community and employment activities. However, mobility-related challenges make physical activity ...
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(2013-07-17)Department: Biomedical EngineeringUnderstanding the contribution of individual mechanical stimuli to cardiovascular pathogenesis is critically important for understanding and treating cardiovascular disease, and microfluidic bioreactors are a useful tool ...
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(2018-11-16)Department: Biomedical EngineeringT cell activity is dysregulated in a number of autoimmune diseases for which systemic lupus erythematosus is a prime example. Treatment options are limited and usually consist of overt immune suppression and compromised ...
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(2005-12-16)Department: Biomedical EngineeringA persistent limitation to current and future anti-cancer therapies is an inability to deliver high levels of active agent throughout the entire target tumor tissue volume without adversely impacting normal tissues. ...
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Development and Characterization of NMR and MRI Methods for Assessment of Tumor Oxygen Consumption (2012-10-08)Department: PhysicsA common feature of invasive cancers is that they have an upregulation of glucose metabolism and reduced oxygen utilization. The overall goal of this research was to develop a 17Oxygen MRI method to access this aberrant ...
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(2015-07-15)Department: PharmacologyThe essential roles of glutamatergic signaling in both normal and impaired cognitive functioning have caused metabotropic glutamate (mGlu) receptors to become targets of interest for the treatment of psychiatric disorders. ...
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(2019-04-08)Department: Biological SciencesOver the years, periodic innovations in fluorescence microscopic technologies have afforded researchers a more sophisticated understanding of the inner workings of the cell. These methods are valuable but drawbacks include ...
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(2013-08-08)Department: Mechanical EngineeringExternally powered transradial prostheses have traditionally been limited to devices that are broad abstractions of the natural hand, possessing a single degree of freedom and having limited grasping capability. Enabled ...
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(2007-07-31)Department: Biomedical InformaticsMass Spectrometry (MS) is emerging as a breakthrough mass-throughput technology believed to have powerful potential for producing clinical diagnostic and prognostic models and for identifying relevant disease biomarkers. ...
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(2010-03-15)Department: Biomedical EngineeringWithin the last decade, magnetic resonance imaging (MRI) scanners with ultra-high magnetic field strengths of 7 Tesla and above have become available. While high magnetic fields provide theoretical improvements in the ...
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(2016-11-17)Department: Biomedical EngineeringAdvanced neuroimaging techniques provide the possibility to non-invasively understand and monitor white matter during development and disease. While data from quantitative MRI techniques, such as multiexponential T2 (MET2) ...