Browsing by Title
Now showing items 3720-3739 of 17439
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(2009-03-12)Department: PhysicsThe primary purpose of this thesis is to detail recent progress in the development of high-brightness cathodes for use in beam driven radiation sources. In particular, diamond field-emitter arrays (DFEA) are discussed and ...
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(2016-03-11)Department: ChemistrySystems biology greatly enhances the study of complex biological processes by expanding on reductionist approaches that have traditionally focused on individual biological components (i.e. glycomics). Systems biology ...
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(2022-10-10)Department: Biomedical EngineeringA broad range of surgical procedures involve working in areas proximal to vital nerves and neural structures. Currently, surgeons rely on their experience, anatomical knowledge, and visual assessment of the surgical field ...
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Development of methods for docking and designing small molecules within the Rosetta code framework (2012-10-15)Department: Chemical and Physical BiologyStructure-based drug design is a key challenge for pharmaceutical chemists. By studying the structure of proteins bound to natural substrates, researchers can design small molecules which they predict will bind in a similar ...
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(2015-04-05)Department: Mechanical EngineeringMicrofluidic systems provide numerous features and advantages that make them well-suited for investigations of interesting phenomena in cell biology. Several microfluidic cell culture platforms were developed to probe cell ...
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(2008-04-07)Department: Biomedical EngineeringEarly detection of breast lesions with malignant potential plays an important role in patient prognosis and survival. While X-ray mammography is the current clinical standard for screening and detection, traditional ...
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(2017-02-03)Department: ChemistryG protein-gated inwardly rectifying potassium (GIRK) ion channels are part of a larger family of inwardly rectifying potassium channels (Kirs) that regulate diverse biological processes. Kirs regulate solute balance in the ...
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(2008-12-22)Department: ChemistryMultianalyte microphysiometry is a real-time method for evaluating cellular metabolism using the multianalyte microphysiometer (MAMP), an instrument capable of measuring extracellular changes in the flux rates of oxygen, ...
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(2008-08-05)Department: Electrical EngineeringCVD diamond is an excellent material for field emission with low electron affinity, robust mechanical and chemical properties, high thermal conductivity, and ability to withstand extreme temperature and radiation. However, ...
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(2021-11-17)Department: Chemical EngineeringWith the emergence of advanced molecular profiling approaches, the heterogeneous landscape of various diseases can now be accurately measured revealing that the “one-size fits all” approach to treatment is ineffective in ...
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(2011-04-15)Department: ChemistryNovel ion mobility-mass spectrometry shift reagents have been developed in order to facilitate rapid identification of specific functionalities within a complex mixture of peptides. Lanthanide chelating labels provide great ...
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(2015-07-21)Department: Chemical and Physical BiologyThe ability to make rapid predictions of macro-molecular structures will enable researchers to carry out effective protein design, virtual High Throughput Screening (vHTS) and rational drug design studies. Here, we describe ...
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(2017-08-25)Department: ChemistryRegenerative medicine and drug delivery strategies require the use of advanced materials that can mimic the complex biological environment of native tissues. We present a series of advanced poly(glycidol) networks that are ...
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(2020-05-29)Department: Chemical EngineeringBacterial biofilms are adherent, treatment-recalcitrant communities that contribute to the chronicity of diseases such as osteomyelitis, a debilitating infection of bone that results in increased morbidity and mortality. ...
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(2012-04-10)Department: ChemistryMetabotropic glutamate (mGlu) receptors are examples of family C G-protein-coupled receptors that possess vast roles in the pathophysiology of central nervous system (CNS) disorders. In order to fully understand the mGlu ...
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(2015-11-23)Department: Biomedical EngineeringPeripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk ...
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(2015-03-11)Department: Biomedical EngineeringA clinical need exists for improved methods to identify cancer patients with tumors prone to drug resistance, and prescribe effective alternative therapies. Cellular metabolism is a powerful marker of tumor response to ...
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(2019-03-12)Department: Biomedical EngineeringThere are no reliable methods to determine how an individual breast or pancreatic cancer patient will respond to a particular treatment option. Patient-derived tumor organoids offer the ability to screen drugs directly on ...
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(2015-04-05)Department: Biomedical EngineeringPeptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
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(2015-07-28)Department: Biomedical EngineeringSensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation ...