Browsing by Title
Now showing items 3730-3749 of 17440
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(2011-04-15)Department: ChemistryNovel ion mobility-mass spectrometry shift reagents have been developed in order to facilitate rapid identification of specific functionalities within a complex mixture of peptides. Lanthanide chelating labels provide great ...
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(2015-07-21)Department: Chemical and Physical BiologyThe ability to make rapid predictions of macro-molecular structures will enable researchers to carry out effective protein design, virtual High Throughput Screening (vHTS) and rational drug design studies. Here, we describe ...
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(2017-08-25)Department: ChemistryRegenerative medicine and drug delivery strategies require the use of advanced materials that can mimic the complex biological environment of native tissues. We present a series of advanced poly(glycidol) networks that are ...
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(2020-05-29)Department: Chemical EngineeringBacterial biofilms are adherent, treatment-recalcitrant communities that contribute to the chronicity of diseases such as osteomyelitis, a debilitating infection of bone that results in increased morbidity and mortality. ...
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(2012-04-10)Department: ChemistryMetabotropic glutamate (mGlu) receptors are examples of family C G-protein-coupled receptors that possess vast roles in the pathophysiology of central nervous system (CNS) disorders. In order to fully understand the mGlu ...
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(2015-11-23)Department: Biomedical EngineeringPeripheral arterial disease (PAD) affects millions of individuals and increases the risk of myocardial infarction, stroke, and mortality. Compared to the general population, diabetic patients have a four times greater risk ...
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(2015-03-11)Department: Biomedical EngineeringA clinical need exists for improved methods to identify cancer patients with tumors prone to drug resistance, and prescribe effective alternative therapies. Cellular metabolism is a powerful marker of tumor response to ...
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(2019-03-12)Department: Biomedical EngineeringThere are no reliable methods to determine how an individual breast or pancreatic cancer patient will respond to a particular treatment option. Patient-derived tumor organoids offer the ability to screen drugs directly on ...
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(2015-04-05)Department: Biomedical EngineeringPeptide-based therapeutics hold significant therapeutic potential for use in a variety of clinical applications ranging from cancer to cardiovascular disease. However, the potential of peptide-based therapeutics is limited ...
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(2015-07-28)Department: Biomedical EngineeringSensitive and specific noninvasive in vivo imaging of contrast agents and endogenous molecules can supply molecular and functional information in animal models, providing essential insight into mechanisms of disease formation ...
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(2018-08-20)Department: Biomedical EngineeringThere is a need for molecular imaging techniques in the eye to better understand disease progression, identify early disease markers, and evaluate new treatment options. Optical coherence tomography (OCT) provides high ...
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(2018-04-16)Department: ChemistryThe three diseases most commonly linked to poverty—malaria, tuberculosis (TB), and HIV/AIDS—are the cause of 8.7 million deaths globally each year. Early and accurate diagnosis of these infectious disease is critically ...
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(2015-04-08)Department: Chemical EngineeringFor the application of cell therapy in tissue repair, there is a compelling need for the development of suitable cell carriers, which will function as synthetic analogs of the extracelluar matrix (ECM) that provide a ...
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(2014-04-15)Department: Chemical EngineeringOverall cancer fatalities have stabilized since the early 1990s, however the prevalence of cancer is still remarkably high for men (45%) and women (38%). While the recent advances in treatments for cancers have increased ...
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Development of prognostic model for breast cancer in Shanghai Breast Cancer Survival Study (SBCSS) (2015-07-23)Department: BiostatisticsWe developed prognostic models to predict five-year overall survival (OS), ten-year overall survival (OS), and five-year relapse-free survival (RFS) from Shanghai Breast Cancer Survival Study (SBCSS). SBCSS is a large, ...
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(2013-04-16)Department: ChemistryDisorders of the central nervous system (CNS) continue to be among mankind’s most devastating illnesses. Along with causing enormous suffering for those affected, mental disorders place an extreme socioeconomic burden on ...
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(2016-12-06)Department: Biomedical EngineeringInflammatory bowel disease (IBD), comprised of Crohn’s disease and ulcerative colitis, is a complex autoimmune condition characterized by periods of disease flare and remission that seriously impact patient quality of life. ...
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(2015-07-22)Department: ChemistryDelivery of diagnostic tools to low-resource settings under the burden of the malaria epidemic faces numerous challenges. These underdeveloped areas are often characterized by poverty, absent or intermittent electricity, ...
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(2017-04-11)Department: ChemistryIn low-resource areas of the world, accurate diagnosis of disease is especially challenging, as resources are limited and environmental conditions uncontrolled. Consequently, reliable low-resource diagnostics must be simple, ...
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(2013-12-12)Department: Biomedical EngineeringA series of novel, physiologically-responsive poly(ε-caprolactone)-co-(α-allyl carboxylate-ε-caprolactone) [x%PCL-y%ACPCL (x and y: molar ratio)] shape memory polymers (SMPs) were synthesized with excellent shape memory ...