Browsing by Title
Now showing items 3862-3881 of 17439
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(2022-01-14)Department: ChemistryThe human neuropeptide Y (NPY) receptor family (Y1R, Y2R, Y4R, and Y5R) are comprised of G-protein coupled receptors (GPCR) that bind the ligands neuropeptide Y (NPY), polypeptide YY (PYY), and pancreatic polypeptide (PP). ...
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(2019-12-12)Department: ChemistryThe metabotropic glutamate (mGlu) receptors belong to the Class C family of G protein-coupled receptors (GPCRs) and are involved with the modulation of neuronal excitability and synaptic transmission within the central ...
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(2014-07-17)Department: Biomedical InformaticsA logical mechanism by which SNPs affect the pathophysiology of disease is through altering the expression of genes. Several studies have explored how SNPs alter expression of nearby genes (cis-eQTLs), but far fewer studies ...
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(2005-10-19)Department: PharmacologyLipoxygenase (LOX) are non-heme iron dioxygenases that form fatty acid hydroperoxides used in membrane remodeling and cell signaling. Mammalian epidermal LOX type 3 (eLOX3) is distinctive in totally lacking this typical ...
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(2021-07-22)Department: ChemistryHerein, we first describe the discovery of the first inhibitor of the inward rectifying potassium channel 4.1/5.1 (Kir4.1/5.1) heterotetramer, VU6036720. The potency and selectivity of VU’720 was established using fluorescence‐ ...
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(2022-08-11)Department: ChemistryClostridioides difficile is a nosocomial gastrointestinal pathogen with a major impact on the healthcare community and limited treatment methods. This pathogen undergoes germination from a dormant spore into a vegetative ...
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(2015-04-20)Department: BiochemistryRas is a small GTPase that functions as a molecular switch, cycling between inactive (GDP-bound) and active (GTP-bound) states. Mutations in Ras fix the protein in the active state and endow tumor cells with the ability ...
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(2019-03-15)Department: BiochemistryCTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite ...
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(2014-07-22)Department: Chemical and Physical BiologyThe muscarinic acetylcholine receptors (mAChRs) are a family of G protein-coupled receptors comprised of five subtypes (M1-5) expressed throughout the central nervous system (CNS). These receptors, together with their ...
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(2010-09-21)Department: PharmacologyThere exist five subtypes of the muscarinic acetylcholine receptor (M1-M5), which are differentially expressed throughout the body and play important roles in numerous physiological processes, including autonomic functions, ...
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(2012-04-09)Department: PharmacologyE-cadherin is a transmembrane protein that maintains intercellular contacts and cellular polarity in epithelial tissues. The down-regulation of E-cadherin is thought to aid in the induction of an epithelial-to-mesenchymal ...
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(2017-08-29)Department: ChemistryProgress toward the first total synthesis of Melearoride A, a macrolide natural product from the marine fungus Penicillium meleagrinum var. viridiflavum. This compound has shown interesting synergistic antifungal activity ...
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2003-06-03)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2005-10-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2006-01-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2006-04-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2006-06-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2006-10-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2007-01-01)
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(Vanderbilt Kennedy Centerhttp://kc.vanderbilt.edu, 2007-04-01)