Browsing by Title
Now showing items 5981-6000 of 17439
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(Molecular Genetics & Genome Medicine, 2019-06)BackgroundEpidemiological studies consistently indicate that alcohol consumption is an independent risk factor for female breast cancer (BC). Although the aldehyde dehydrogenase 2 (ALDH2) polymorphism (rs671: Glu>Lys) has ...
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(2016-03-04)Department: Microbiology and ImmunologyClostridium sordellii infections cause gangrene and edema in humans and gastrointestinal infections in livestock. The two principle virulence factors, TcsH and TcsL, are highly homologous to C. difficile TcdA and TcdB, ...
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(2007-03-14)Department: Microbiology and ImmunologyProtein synthesis is a complex and poorly understood process that requires the concerted activity of ribosomes and a plethora of trans-acting protein factors. This dissertation used proteomic, biochemical, and functional ...
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(2004-12-12)Department: Microbiology and ImmunologyExperimental and epidemiological studies have suggested that the vacuolating cytotoxin (VacA) is an important H. pylori virulence factor that contributes to the development of peptic ulceration and gastric adenocarcinoma. ...
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(2023-03-29)Department: Cell & Developmental BiologyIn pancreatic beta cells, molecular motors use cytoskeletal polymers microtubules as tracks for intracellular transport of secretory insulin granules. Beta-cell microtubule network has a complex architecture, which allows ...
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(2014-03-29)Department: Cell and Developmental BiologyMicrotubule-associated proteins (MAPS) frequently influence microtubule (MT) dynamics and may also alter MT-dependent processes, such as protein trafficking. RASSF1A is a MAP that is frequently silenced in most human ...
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(2014-09-16)Department: BiochemistryCytochrome P450s are versatile biocatalysts that play crucial roles in many important biological processes. Functional annotation of orphan P450 enzymes is the focus of this work. Catalytic activities of orphan human P450 ...
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(2020-11-03)Department: NeuroscienceAMPA receptors (AMPAR) are key mediators of fast excitatory neurotransmission within the brain. The functional identity of AMPAR at the synapses strongly contributes to molecular mechanisms of learning and memory. At the ...
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(2012-05-25)Department: PharmacologyMutations in inhibitory GABAA receptor γ2 subunit gene, GABRG2, have been associated with genetic epilepsy syndromes including childhood absence epilepsy (CAE), pure febrile seizures (FS), generalized epilepsy with febrile ...
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(2013-11-18)Department: Biological SciencesThis dissertation is concerned with the expression patterns, functionality and mechanisms of disease vector mosquito odorant receptors. The principal afrotropical vector for malaria, Anopheles gambiae, discriminates human ...
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(2022-05-09)Department: NeuroscienceThis dissertation work comprises a functional characterization of R294X and representative C-terminal stop loss MECP2 mutations that cause Rett syndrome (RTT) in people. In Chapter 2, we show that RTT-like phenotypes induced ...
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(2022-06-14)Department: Microbe-Host InteractionsGram-negative bacteria are frequently opportunistic pathogens that cause significant morbidity and mortality in humans. Escherichia coli and Klebsiella pneumoniae are two common Gram-negative pathogens that often acquire ...
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(2020-07-20)Department: Special EducationChildren with intellectual and developmental disabilities (IDD) frequently engage in escape-maintained problem behavior, which can limit their access to academic instruction and lead to placement in more restrictive ...
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(2006-10-06)Department: Molecular BiologyThis project was concerned with the functional components of mammalian DNA replication origins and how the misuse of a start site for DNA replication at the FMR1 locus might contribute to human Fragile X Syndrome. In ...
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(2017-11-28)Department: Biomedical EngineeringThe identification of patterns of highly correlated low frequency Magnetic Resonance Imaging (MRI) signals in resting states provides a powerful approach to assess brain functional organization. However, functional MRI ...
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(2008-04-04)Department: Biological SciencesHuman replication protein A (RPA) is a single-stranded DNA (ssDNA) binding protein involved in DNA metabolism. RPA binds ssDNA transiently during initiation of DNA replication. When this dissertation research began, the ...
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(2013-04-18)Department: PsychologyIt has long been recognized that people demonstrate orienting responses to novel, salient stimuli in the environment. The presentation of such an oddball stimulus does not only induce physiological, reflexive responses, ...
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(2016-11-17)Department: BiochemistryOxidative stress is a contributing factor in a number of chronic diseases, including cancer, atherosclerosis, and neurodegenerative diseases. Lipid peroxidation that occurs during periods of oxidative stress and decomposition ...
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(2020-08-20)Department: Electrical EngineeringFunctional magnetic resonance imaging (fMRI) is widely used to study the characteristics of the human brain activities. Most of the analysis methods are based on voxels. Some summary statistics characterizing the temporal ...
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(2022-06-28)Department: PsychologyWhen brain networks deviate from typical development, it is thought to contribute to varying forms of psychopathology. However, research has been limited by the reliance on discrete diagnostic categories that overlook the ...