Browsing by Title
Now showing items 6091-6110 of 17439
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(2018-10-19)Department: Biological SciencesRecent advances in sequencing technology have greatly decreased the cost and increased the availability of genomic data. Armed with this rich base of information, it has become feasible to pursue the study of complex ...
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(2013-04-19)Department: Cell and Developmental BiologyNinjurins are a conserved family of transmembrane proteins that increase expression in response to injury and stress. There are few in vivo studies of Ninjurin, and little is known about Ninjurin function. In this thesis ...
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(2013-06-04)Department: BiochemistryThis dissertation focuses on the biochemical and genetic characterization of the protein-protein interaction in the budding yeast Saccharomyces cerevisiae between the cytosolic translation initiation guanine nucleotide ...
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(2013-03-29)Department: NeuroscienceIn the brain, serotonin (5-hydroxtryptamine, 5-HT) is synthesized in the raphe nucleus. Raphe serotonergic projections modulate neurotransmissions throughout the brain influencing mood and behavior. The serotonin transporter ...
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(2023-05-04)Department: Biological SciencesFragile X syndrome (FXS) is an inherited intellectual disability and autism spectrum disorders. Most FXS patients have a total loss of Fragile X Mental Retardation Protein (FMRP) resulting from the epigenetic silence of ...
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(2005-03-09)Department: Molecular Physiology and BiophysicsAutism is a severe neurodevelopmental disorder characterized by deficits in language and social interaction, and patterns of repetitive and stereotyped behaviors, interests and activities. Evidence indicates that autism ...
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(2019-02-13)Department: PharmacologyDopamine (DA) signaling plays an important role in the central nervous system by regulating a variety of functions including attention, motivation, reward, movement and courtship. Alterations in DA signaling have been ...
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(Vanderbilt University. Writing Studio, 2009-03-22)
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(2008-04-10)Department: ReligionThis dissertation elaborates and evaluates the proprieties of genetic counseling as they are accounted for in three models: 1) the teaching model 2) the psychotherapeutic model and 3) the responsibilist model. The ...
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(2014-11-25)Department: Biological SciencesABSTRACT Synapse formation is driven by precisely orchestrated intercellular communication between presynaptic and postsynaptic cells. Signals traverse a complex extracellular environment, where glycans attached to ...
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(2013-04-22)Department: NeuroscienceSKF83959 is a high affinity dopamine D1 receptor agonist that has been reported to preferentially activate D1 receptors coupled to G(alpha)q. This pathway results in phosphatidylinositol hydrolysis, intracellular calcium ...
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(2022-09-14)Department: Human GeneticsDespite a 1% prevalence of stuttering in the general adult population, developmental stuttering, characterized by blocks, repetitions, and prolongation of sounds in speech with a childhood onset, persists as a largely ...
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(2011-04-07)Department: NeuroscienceCurrent estimates suggest that as many as 9% of Americans meet the DSM-IV criteria for substance use disorders, and the annual economic burden of substance abuse has been assessed at approximately half a trillion dollars. ...
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(International Journal of Epidemiology, 2019-06)Background: Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score ...
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(2008-04-15)Department: NeuroscienceNeuroscience Dissertation under the direction of Professor Randy D. Blakely This dissertation is focused on the function and regulation of the choline transporter (CHT). I used CHT heterozygous and homozygous mice, and ...
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(2017-11-21)Department: EpidemiologyPrevious pharmacogenetics studies of 5-fluorouracil (5-FU) have focused on coding variants, and only four of these variants showed consistent association, which explained a small fraction of the heritability of 5-FU-associated ...
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(2008-03-05)Department: Cancer BiologyThere is a significant genetic component to prostate cancer (PrCa) risk. Multiple epidemiologic and linkage studies suggest X-linked heritability. Located at chromosome Xq27-28, HPCX has been identified as a PrCa susceptibility ...
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(2019-05-08)Department: Microbiology and ImmunologyAdverse reactions to drugs are a threat to individual safety and quality of life. Two of the severest reactions, Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) and Drug Reaction with Eosinophilia and Systemic ...
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(2014-10-29)Department: NeuroscienceEpilepsy is a common neurological disease characterized by an enduring predisposition to generate seizures. Although multiple factors contribute to epilepsy, the majority of cases are genetic in origin. Variable expressivity ...
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(2016-11-03)Department: PharmacologyThe application of genome science to inherited heart disease requires accurate genetic evaluation and understanding of physiologic resulting from genetic variation. Using a Long QT syndrome phenotype that is very suggestive ...