Browsing by Title
Now showing items 7120-7139 of 17382
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(2017-08-09)Department: Molecular Physiology and BiophysicsThe two-pore domain K<sup>+</sup> (K2P) channel TALK-1 is highly expressed in the pancreatic islet and is linked to type 2 diabetes mellitus (T2DM) risk through a non-synonymous polymorphism (rs1535500). Here, we established ...
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(2015-03-13)Department: BiochemistryCoordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during catalysis. Because the activities of these domains are tightly linked, ...
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(2021-06-14)Department: PharmacologyKCC2 is a K+-Cl- cotransporter with neuronal expression throughout the central nervous system. Deficits in KCC2 activity have been implicated in a variety of neurological disorders, including epilepsy, chronic pain, autism ...
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(2011-11-22)Department: Biological SciencesFragile X syndrome, resulting from the loss of function of the hFMR1 gene, is the most common heritable cause of intellectual disability. The human genome also encodes two closely related paralogs: hFXR1 and hFXR2. Drosophila ...
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(2017-03-23)Department: NeuroscienceThe ability to integrate information across the senses is vital for coherent perception of and interaction with the surrounding world. In the mammalian brain, the superior colliculus (SC) is critical for this multisensory ...
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(2014-02-11)Department: PharmacologyThe production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
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(2005-04-19)Department: Biological SciencesBIOLOGICAL SCIENCES INSIGHTS INTO THE ROLES OF HUMAN CDC6 AND REPLICATION PROTEIN A IN INITIATION OF EUKARYOTIC DNA REPLICATION VITALY VLADIMIROVICH KLIMOVICH Dissertation under the direction of Professor Ellen H. ...
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(Vanderbilt University. Peabody College, 2008-07-28)Motivation is a key ingredient in the elementary classroom. When students are intrinsically motivated to learn, they learn more effectively. While some students enter the classroom with a high-degree of motivation, many ...
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(2013-07-29)Department: Microbiology and ImmunologyCD4+ T cells developing toward a Th2 fate express IL-4, IL-5, and IL-13 while inhibiting production of cytokines associated with other Th types, such as the Th1 cytokine IFN-γ. IL-4–producing Th2 effector cells give rise ...
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(2016-03-10)Department: Mechanical EngineeringCombustion at the conditions found in practical applications is extremely complex and must be well characterized to support the next generation of combustors. This task is extremely difficult both experimentally and ...
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(2007-07-26)Department: Spanish and PortugueseThis project explores the mechanisms of appropriation and re-elaboration of the metropolitan Baroque discourse by educated criollos in Colonial Peruvian society. Examining Juan de Espinosa Medrano’s works (which include a ...
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(American Schools of Oriental Research, 1968)
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(2007-04-17)Department: Leadership and Policy StudiesINSTITUTIONAL CHARACTERISTICS AND ENVIRONMENTAL FACTORS THAT INFLUENCE PRIVATE GIVING TO PUBLIC COLLEGES AND UNIVERSITIES: A LONGITUDINAL ANALYSIS YING LIU In recent years, increasing market competitiveness and ...
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(Vanderbilt Law Review, 1999)This Article applies comparative institutional analysis to separation of powers under state constitutions, with a particular focus on the nondelegation doctrine and states' acceptance of Chadha-like restrictions on legislative ...
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(Vanderbilt University, 2008)
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(Vanderbilt University, 2011)
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(HEPATOLOGY COMMUNICATIONS, 2019-07)The accumulation of excess fat in the liver (hepatic steatosis) in the absence of heavy alcohol consumption causes nonalcoholic fatty liver disease (NAFLD), which has become a global epidemic. Identifying metabolic risk ...
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(Journal of Personalized Medicine, 2018)Abstract: Insurance coverage policies are a major determinant of patient access to genomic tests. The objective of this study was to examine differences in coverage policies for guideline-recommended pharmacogenomic tests ...
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(Vanderbilt Law Review, 2006)Insurers play a critical role in the civil justice system. By providing liability insurance to parties who would otherwise be untenable as defendants, insurers make litigation possible. Once litigation materializes, insurers ...
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(Vanderbilt University, 2017)This work examines the political transformations in Northern Ireland after the Belfast Peace Agreement of 1998 ended 30 years of conflict between the country’s Protestant, Unionist and Catholic, Nationalist communities. ...