Browsing by Title
Now showing items 7397-7416 of 17440
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(Vanderbilt University, 2022-03-28)Adverse Childhood Experiences (ACEs) predispose adolescents to a variety of physical and mental health problems and place them at an increased risk of experiencing additional major stressors later in life (Anda et al., ...
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(2012-04-11)Department: Biomedical EngineeringMagnetic resonance imaging (MRI) provides methods for characterizing tissue micro-structure using relaxation-based measurements with and without the use of contrast agents (CA). Two techniques, dynamic contrast enhanced ...
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(2015-03-23)Department: Human GeneticsCommon age, related eye diseases are a major driving force behind vision disability and blindness. The three most common diseases afflicting Americans today are age-related macular degeneration (AMD), primary open-angle ...
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(2020-11-19)Department: Microbe-Host InteractionsHelicobacter pylori colonizes the stomach in about half of the world’s population. Gastric colonization with H. pylori strains containing the cag pathogenicity island (cag PAI) is a risk factor for gastric adenocarcinoma ...
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(2012-11-15)Department: Mechanical EngineeringComputational modeling of the Madaras wind turbine is presented in this thesis. First, comparative studies were performed based upon literature results to validate the accuracy of the computational model. Then, the Madaras ...
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(The RAND Journal of Economics, 2012)After developing a conceptual analysis of consumer valuation of multiple risks, we explore both economic and cognitive hypotheses regarding individual risk-taking. Using a sample of over 1,500 consumers, our study ...
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(2020-11-20)Department: Chemical & Physical BiologyFaithful duplication of DNA lies at the center of DNA replication, defects in which can lead to cancer and other diseases of genomic instability. Generating copies of the two stands of the DNA duplex begins with synthesis ...
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(2005-12-06)Department: ChemistryThe stereo structures of variety chiral molecules were studied by vibrational circular dichroism (VCD), optical rotation (OR), and density functional theory in this dissertation. The error ranges in the density functional ...
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(2018-04-02)Department: Computer ScienceThe stochastic gradient descent algorithm for training neural networks is widely used in many machine learning, especially deep learning tasks. The stochastic gradient descent algorithm operates by choosing a small fraction ...
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(2013-12-09)Department: BiochemistryThe G protein coupled receptor (GPCR) family is comprised of ubiquitous, membrane-bound proteins that are highly conserved in structure, yet varied in their cognate ligand. This allows for regulation of diverse physiological ...
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(2015-05-28)Department: Molecular Physiology and BiophysicsPdx1 is a transcription factor of fundamental importance to pancreas formation and adult islet β-cell function. However, little is known regarding its role in mature β-cells or the positive- and negative-acting coregulators ...
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(2008-02-05)Department: Human GeneticsSpontaneous preterm birth (PTB), gestational age less than 37 weeks, is a major public health problem worldwide. Almost 500,000 preterm births occur annually in the United States (U.S.), accounting for ~12% of deliveries. ...
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(2015-11-19)Department: ChemistryMechanochemical methods of synthesis (specifically grinding and milling) have not yet been widely used by organometallic chemists. This thesis surveys recent developments in the field, outlining differences that can occur ...
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(2010-08-24)Department: PsychologyThis dissertation aims at investigating the role of early visual cortex in music reading expertise. This work was motivated by the surprising finding of neural selectivity for musical notes in early visual cortex with music ...
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(2011-02-15)Department: Microbiology and ImmunologySeveral viruses are known to induce stress granules (SGs), however, a role for these structures during viral infection remains unknown. We first showed that respiratory syncytial virus (RSV) induces SGs starting approximately ...
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(2022-08-17)Department: ChemistryThe endoplasmic reticulum (ER), responsible for processing approximately one-third of the human proteome including most secreted and membrane proteins, plays a pivotal role in protein homeostasis (proteostasis). Dysregulation ...
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(2016-07-14)Department: ChemistryMalaria is an entirely preventable and treatable disease, yet it is endemic in nearly half of the countries around the world. One of the most important drug targets for this disease is the hemozoin formation pathway, a ...
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(2021-06-14)Department: PhysicsThe shortage of 3He has driven a worldwide search for solid-state neutron detection devices. The detector materials for these devices respond to incident radiation by either producing photons through scintillation mechanisms ...
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(2017-02-15)Department: ChemistryThis work describes three separate projects, for which Density Functional Theory (DFT) computations provide a unifying theme. The DFT approach gives a theoretically sound way to model the chemical and physical properties ...
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(2015-12-16)Department: ChemistryOrthosomycins are highly decorated oligosaccharides with potent activity against a variety of Gram-positive bacteria including methicillin-resistant staphylococci and vancomycin-resistant enterococci. The research in this ...