Browsing by Title
Now showing items 970-989 of 17440
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(2020-04-03)Department: Microbe-Host InteractionsMosquito inoculation of humans with arthritogenic alphaviruses results in a febrile syndrome characterized by debilitating musculoskeletal pain and arthritis. Despite an expanding global disease burden, no approved therapies ...
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(2010-12-04)Department: Cell and Developmental BiologyThis project is concerned with understanding the role of the mRNA-binding protein Nab2 in the process of nuclear mRNA export. In this dissertation I characterize changes that occur to Nab2’s structure and localization ...
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(Vanderbilt University. Peabody College, 2010-05)
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(2022-10-17)Department: Chemical & Physical BiologyThe inositol 1,4,5triphosphate (IP3) receptor (IP3R) mediates Ca2+ release from the endoplasmic reticulum (ER) to control cytoplasmic and organellar Ca2+ concentrations. IP3Rs are co-activated by IP3 and Ca2+, inhibited ...
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(Vanderbilt University, 2010-01-05)The zodiac, a pagan symbol believed to have originated in 7th century BCE Babylonia, appears in the floor mosaics of numerous synagogue ruins through the Palestine region, including one found in a fifth century synagogue ...
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(2006-12-21)Department: Electrical EngineeringTotal ionizing dose effects in a low-dropout voltage regulator are explained based on experimental data and circuit simulations. Transistor gain degradation is shown to be the dominant cause of the circuit degradation at ...
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(2012-04-13)Department: Nursing ScienceWhile researchers have found written emotional disclosure to be beneficial for psychological health, physical health, and overall functioning in certain populations, no one has definitively ascertained how or why this ...
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(2010-08-13)Department: Biological SciencesMyotonic dystrophy type 2 (DM2) is an autosomal dominant human disease caused by the expansion of a tetranucleotide repeat in the first intron of the ZNF9 gene. While multiple studies link nucleotide expansions such as ...
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(2021-04)Importance: Although prior research has documented higher rates of incarceration among sexual minorities, little research has examined the intersections of the justice-involved and sexual minority populations. Research is ...
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(2006-07-21)Department: PhysicsSince September 11, 2001, the safety and security of the U.S. nuclear reactor complex has become a topic of controversy. Due to the safety features afforded to reactor vessels, most experts agree that the focus should be ...
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(2017-01-27)Department: Mechanical EngineeringOtology and neurotology are surgical specialties focusing on the treatment of ear diseases. A key component of many otologic and neurotologic surgical procedures is the removal of a portion of the skull behind the ear to ...
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(Vanderbilt University. Dept. of Physics and Astronomy, 2021-12)The possibility to control quantum systems with photons has stimulated recent interest in the study of quantum optical systems. While simple classical quantum systems admit well-known solutions, analysis of light-coupling ...
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(2023-11-15)Department: Mechanical EngineeringEnergetically passive devices are rigid and complaint mechanisms that can amplify force as well as store and release energy with specific timings and forces. Designing a compliant mechanism for a given task, i.e “inverse ...
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(2021-03-12)Department: Electrical EngineeringAutism Spectrum Disorders (ASD) are a group of developmental disabilities characterized by difficulties in social communication and repetitive or restricted behaviors and interests. According to the latest CDC report, 1 ...
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(2020-04-03)Department: AstrophysicsThe light curve has taken on a new importance in the field of astrophysics in the 21st century. Next generation telescopes such as the Vera C. Rubin Observatory and the Wide Field Infrared Survey Telescope (WFIRST) will ...
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Analyzing genome integrity during DNA replication using iPOND (isolation of Proteins On Nascent DNA) (2013-07-12)Department: BiochemistryThe in vivo analysis of dynamic events that protect genomic and epigenomic integrity during DNA replication has been a challenging task. The proteins that ensure the accurate inheritance of the genome act directly at ...
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(2021)The purpose of this study was to investigate agenda-setting activity relevant to maternal mortality by using social media data. The study ultimately sought to determine what subset(s) of social media users dominate ...
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(2018-07-26)Department: HistoryThis dissertation examines the role that various publics have played in the creation and transmission of scientific knowledge of the human body at work. It focuses on the early development of industrial psychology as a way ...
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(2015-03-09)Department: Cancer BiologyLIM domain Only-2 (LMO2) is a T cell oncogene whose molecular mechanism for T-cell transformation still remains to be elucidated. There are two hypotheses that could explain how the enforced expression of LMO2 induces ...