Browsing by Author "Alissa M. Weaver"
Now showing items 1-11 of 11
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Almodóvar García, Karinna (2014-07-22)Department: PathologyNormal tissue repair involves a series of highly coordinated events that include inflammation, granulation tissue formation, revascularization, and tissue remodeling. The transcriptional co-factor, ankyrin repeat domain ...
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Cleghorn, Whitney Marie (2012-06-22)Department: PharmacologyArrestins bind G protein-coupled receptors and more than 100 non-receptor partners, regulating various signaling pathways and cellular functions. The interactions of many proteins (e.g., Src, JNK3, ERK½, Mdm2, etc.) with ...
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Ashby, William Joseph (2012-10-18)Department: Chemical and Physical BiologyCurrent medical ability to diagnose and treat disease remains limited for many chronic diseases such as cancer, carcinoids, diabetes, and obesity. Basic research promises to advance our understanding of such conditions and ...
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Panaccione, Alexander Colin (2016-04-04)Department: Cancer BiologySalivary adenoid cystic carcinoma (ACC) is prone to perineural invasion, late recurrence, and distal metastases, with 20-year survival of only 10%. Research defining new targets in ACC has lagged largely due to a dearth ...
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McConnell, Russell E. (2010-03-22)Department: Cell and Developmental BiologyEpithelial cells lining the lumen of the small intestine, called enterocytes, possess an exquisitely ordered array of microvilli collectively referred to as the brush border (BB). Microvilli are actin-rich membrane protrusions ...
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Smith, Andrew Leslie (2011-04-02)Department: Cancer Biologyp120 catenin (p120) binds and stabilizes classical cadherins, making it a critical regulator of cell-cell adhesion. Here, we report an efficient technique (designated ReCLIP for Reversible Cross-Link Immuno-Precipitation) ...
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Grieb, Brian Charles (2014-07-22)Department: PathologyAlthough the MYC transcription factor was discovered over three decades ago and is dysregulated in the majority of human cancers, its regulation remains incompletely understood and there is no pharmacologic means to inhibit ...
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Bristow, Jeanne Malloy (2010-01-08)Department: Biological SciencesBIOLOGICAL SCIENCES THE RHO FAMILY GEF ASEF2 REGULATES ADHESION DYNAMICS AND THEREFORE CELL MIGRATION BY MODULATING RAC AND RHO ACTIVITY JEANNE MALLOY BRISTOW Dissertation under the direction of Assistant Professor Donna ...
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Carrington, Leolene Jean (2016-03-30)Department: Biological SciencesNon-muscle myosin II (MyoII) contractility is important to the regulation of many cellular processes, including migration. The small GTPase Rho has been shown to regulate MyoII contractility, but the role of other GTPases, ...
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Hong, Nan Hyung (2015-03-19)Department: Cancer BiologyThe branched actin regulator cortactin is a central element connecting signaling pathways with the actin cytoskeleton and plays a role in diverse cellular processes. Cortactin-mediated actin assembly is known to contribute ...
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Wegner, Adam Michael (2008-03-27)Department: NeuroscienceChanges in the number, size, and shape of dendritic spines are associated with synaptic plasticity, which underlies cognitive functions such as learning and memory. This plasticity is attributed to reorganization of actin, ...