Browsing by Author "Alyssa H. Hasty"
Now showing items 1-9 of 9
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Palmisano, Brian T. (2016-11-03)Department: Molecular Physiology and BiophysicsElevated plasma triglycerides (TGs) increase risk of cardiovascular disease, especially in women. Estrogen treatment raises plasma TGs in women, but molecular mechanisms remain poorly understood. Here, I explore the role ...
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Korwek, Kimberly (2009-08-11)Department: NeuroscienceDissertation under the direction of Professor Edwin J. WEeber Apolipoprotein E (apoE) interacts with lipoprotein receptors in the hippocampus. These receptors are intimately involved in the modulation of synaptic plasticity, ...
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Coate, Kathryn Eileen Colbert (2011-08-24)Department: Molecular Physiology and BiophysicsThe goal of this dissertation was to elucidate the metabolic and hepatocellular consequences associated with chronic consumption of a high-fat, high-fructose diet (HFFD), focusing on perturbations in the regulation of HGU ...
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Mitchell, Sabrina L. (2010-12-07)Department: Human GeneticsNeither genome size nor gene number is indicative of organism complexity. Complex regulation of genes within a genome likely contributes to organism complexity. Coordinate regulation of genes through shared cis regulatory ...
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Aamodt, Kristie Irene (2015-07-16)Department: Molecular Physiology and BiophysicsReduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
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Egnatchik, Robert Anthony (2014-04-14)Department: Chemical EngineeringLipotoxicity from free fatty acid overload has been implicated in a variety of diseases including type II diabetes and non-alcoholic fatty liver disease (NAFLD). Incubation of hepatic cells in vitro with saturated fatty ...
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Rojas, Jennifer Marie (2013-03-22)Department: Molecular Physiology and BiophysicsElevated very low-density lipoprotein (VLDL)-triglyceride (TG) secretion from liver contributes to atherogenic dyslipidemia that is associated with obesity, diabetes, and the metabolic syndrome. Numerous models of obesity ...
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Mulligan, Kimberly Xaviera (2012-03-25)Department: Molecular Physiology and BiophysicsSkeletal muscle is an important site for the maintenance of glucose metabolism. Under insulin-stimulated conditions it accounts for ~80% of whole body glucose disposal. Muscle glucose uptake (MGU) is a three step process ...
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Loperena Cortes, Roxana (2018-08-02)Department: Molecular Physiology and BiophysicsIt is increasingly evident that inflammation and immune activation occur in hypertension, by mechanisms that are poorly understood. Monocytes play an important role in hypertension. Circulating monocytes in humans exist ...