Browsing by Author "Alyssa Hasty"
Now showing items 1-16 of 16
-
Wylezinski, Lukasz Szczepan (2016-11-30)Department: Molecular Physiology and BiophysicsThe pleiotropic cytokine interleukin 2 (IL2) disrupts the blood-brain barrier and alters brain microcirculation, underlying vascular leak syndrome that complicates cancer immunotherapy with IL2. The microvascular effects ...
-
Mendonsa, Alisha Maria (2014-12-31)Department: Cancer BiologyNon alcoholic fatty liver disease (NAFLD), is recognized as the one of the most common causes of liver disease in the United States and worldwide. NAFLD is associated with increased risk of development of hepatocellular ...
-
Hickman, Francis Edward (2018-07-17)Department: NeuroscienceThe p75 neurotrophin receptor (p75NTR) plays an integral role in patterning the sympathetic nervous system during development. Initially, p75NTR is expressed at low levels as sympathetic axons project toward their targets, ...
-
Stouch, Ashley Nicole (2014-12-31)Department: Cell and Developmental BiologyBronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
-
Day, Charles Asher (2013-04-19)Department: Molecular Physiology and BiophysicsThe plasma membrane is highly organized as a means to regulate various processes including sorting of cargo for endocytosis. However, the mechanisms responsible for this organization are poorly understood. The B subunit ...
-
Norlander, Allison Elizabeth (2017-03-29)Department: Molecular Physiology and BiophysicsHypertension is a leading cause of cardiovascular morbidity and mortality, leading to myocardial infarction, heart failure, stroke, and chronic kidney disease. We have previously shown that the pro-inflammatory cytokine ...
-
Buckman, Laura Beth (2014-06-27)Department: Molecular Physiology and BiophysicsIn the past decade, evidence has emerged that obesity induces a neuroinflammatory response in the hypothalamus, a part of the brain that contains neuronal circuitry controlling feeding and metabolism. The potential ...
-
Everett Grueter, Carrie Alicia (2006-12-06)Department: Molecular Physiology and BiophysicsGlucoregulatory hormones tightly control glucose production and uptake by their direct actions on glucose metabolism and indirect actions on both lipid and protein metabolism. Our laboratory and others have shown that the ...
-
Anderson, Emily Kathleen (2013-04-11)Department: Molecular Physiology and BiophysicsObesity is a prevalent disorder that increases the risk of developing many metabolic diseases, including insulin resistance (IR) and type 2 diabetes. Research conducted in the past decade has shown that accumulation of ...
-
Jeff, Janina Maria (2012-03-07)Department: Human GeneticsCardiovascular disease (CVD) is the leading cause of death in most developed countries. In addition to environmental risk factors, such as diet and physical activity, genetic risk factors contribute to the CVD risk. Risk ...
-
Dale, Bethany Lyn (2019-04-30)Department: Molecular Physiology and BiophysicsThe role of T and B cells of the adaptive immune have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin ...
-
The Intersection of Maternal Inflammatory Stress and the Developmental Origins of Health and Disease Barke, Theresa Leigh (2019-03-20)Department: Microbiology and ImmunologyThe most important factor influencing the prenatal environment is the maternal environment. There is a growing body of evidence suggesting that the maternal and intrauterine milieu, through the action of inflammatory ...
-
Sullivan, Chelsea Suzanne (2014-10-01)Department: BiochemistryDuring development of the nervous system, approximately 50% of the neurons generated undergo apoptosis as part of a normal pruning process. The neuronal corpses must be efficiently cleared to prevent an immune system ...
-
Sedgeman, Leslie Roteta (2018-10-31)Department: Molecular Physiology and BiophysicsmicroRNAs (miRNA) have been shown to be critical players in metabolism. While most miRNAs studies have focused on their functional role within cells, miRNAs are also found extracellularly and have been proposed to participate ...
-
Johnson, Kathryn Mercedes Stettler (2008-05-05)Department: Molecular Physiology and BiophysicsGlucagon-like peptide-one (GLP-1) secreted from the endocrine L cell in the gut after a meal results in elevations of the peptide in arterial blood, the hepatic portal vein (~2x arterial levels) and vasculature in the gut ...
-
Potter, Leah Ashley (2011-12-04)Department: Molecular Physiology and BiophysicsPluripotent stem cells, because of their ability to differentiate into any cell type, have been widely advocated as a means of producing a nearly unlimited source of new insulin-producing β cells for the treatment of ...