Browsing by Author "Ambra Pozzi"
Now showing items 1-20 of 25
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Violette, Katie (2011-08-16)Department: Cell and Developmental BiologyEvaluation of late events in cardiovascular development is precluded mid-gestational embryonic lethality associated with most traditional endothelial specific gene knockouts. Thus, it has not been possible to study late ...
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Winters, Nichelle Irene (2012-08-06)Department: Cell and Developmental BiologyMesothelium is a simple squamous epithelium that forms the surface layer of all coelomic cavities and organs. Despite its widespread localization, mesothelial development has been studied almost exclusively in the heart. ...
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McCall-Culbreath, Karissa Denise (2008-07-16)Department: Microbiology and ImmunologyThe á2â1 integrin is expressed on many cell types throughout the immune system. Expression of the á2â1 integrin on mast cells is required for the early innate immune response to Listeria monocytogenes. Interaction between ...
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Irvin, Michael Warren (2012-01-25)Department: Biomedical EngineeringThis project is concerned with in vitro assays of angiogenesis and how mechanical stimuli are controllably incorporated into them. The vascular explant assay is considered the most physiologically realistic in vitro ...
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Zhang, Xi (2010-04-20)Department: Cancer BiologyThe major goal of this thesis is to examine the role of beta1 integrin in kidney development. Our results indicate that beta1 integrin is necessary for ureteric bud branching morphogenesis and maintenance of collecting ...
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Pickup, Michael William (2013-10-11)Department: Cancer BiologyDissertation under the direction of Professor Harold L. Moses Transforming Growth Factor Beta (TGF-β) is acts as both a tumor suppressor and promoter in the context of epithelial tumor progression. In epithelial cells, ...
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Lai, Caroline Ming-Hwei (2013-12-04)Department: Microbiology and ImmunologyBloodstream spread is an essential step in the pathogenesis of many viruses. However, mechanisms that promote viremia are not well understood. Reoviruses are neurotropic viruses that disseminate systemically through the ...
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Dise, Rebecca Susanne (2006-04-20)Department: Cell and Developmental BiologyThe lining of the gastrointestinal tract, a single layer of epithelial cells, forms a dynamic barrier that protects the organism from harmful substances present in the lumen. Maintenance of a healthy gastrointestinal tract ...
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Rogers, Meredith Claire (2018-08-29)Department: Microbiology and ImmunologyViral respiratory infections, including infection by human metapneumovirus (HMPV), are associated with T cell impairment, wherein CD8+ T cells exhibit diminished production of cytokines and cytotoxic molecules. In this ...
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Copeland, Courtney Amanda (2017-02-08)Department: Molecular Physiology and BiophysicsCaveolin-1 (CAV1) is an essential protein for the formation of caveolae, invaginations found at the plasma membrane. Caveolae are abundant in many cell types and numerous functions have been identified, including modulating ...
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Aamodt, Kristie Irene (2015-07-16)Department: Molecular Physiology and BiophysicsReduced pancreatic β cell mass is a hallmark of diabetes, which makes the ability to increase or restore β cell mass a major therapeutic goal. While testing the hypothesis that increased endothelial cell signaling would ...
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Bonner, Jeffrey Scott (2013-05-28)Department: Molecular Physiology and BiophysicsThis project investigated the significance of extramyocellular barriers to the pathogenesis of skeletal muscle insulin resistance and their potential as therapeutic targets. The goals of this dissertation were to determine ...
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Ardestani, Shidrokh (2013-07-31)Department: PathologyTNF-α, produced by most malignant cells, orchestrates the interplay between malignant cells and myeloid cells, which have been linked to tumor growth and metastasis. Although TNF-α can exist as one of two isoforms, a ...
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Sinnamon, Mark J (2008-04-22)Department: Cancer BiologyMatrix metalloproteinases (MMPs) are classically associated with late stage metastases, though previous work by our lab and others have expanded the role of MMPs to all stages of tumor development. Using a genetic model ...
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Zhuang, Guanglei (2010-04-10)Department: Cancer BiologyThe Eph family of receptor tyrosine kinases has important roles in multiple aspects of cancer development and progression. Substantial advances have been made in understanding the Eph receptor signalling in the pathways ...
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Crooke, Cornelia Elizabeth (2009-04-21)Department: BiochemistryPhospholipase C-γ1 (PLC-γ1) mediates cell adhesion and migration through an undefined mechanism. Here, we examine the role of PLC-γ1 in cell-matrix adhesion in a hanging drop assay of cell aggregation. Plcg1 Null (-/-) ...
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Bartlett, Christina Swan (2012-12-12)Department: PharmacologyHypertension is a prevalent disease affecting one in three adults in the United States. Approximately 25 % of the adult population is either not receiving therapy for their hypertension or is unable to control their blood ...
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Albertolle, Matthew Edward (2019-01-30)Department: BiochemistryMammalian cytochrome P450 (P450) enzymes catalyze complex reactions involved in the biosynthesis of endogenous metabolites such as steroids, vitamins, and hormones. Additionally, several enzymes in this superfamily are ...
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Riggins, Karen Shakita (2010-09-01)Department: Cancer BiologyThe major goal of this thesis is to investigate the role of MT1-MMP in kidney development. Our results demonstrate that loss of MT1-MMP leads to a renal phenotype characterized by a moderate decrease in ureteric bud branching ...
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Dale, Bethany Lyn (2019-04-30)Department: Molecular Physiology and BiophysicsThe role of T and B cells of the adaptive immune have been implicated in hypertension, but the mechanisms by which they produce a coordinated response is unknown. T follicular helper (Tfh) cells that produce interleukin ...