Browsing by Author "Andrew J. Link"
Now showing items 1-11 of 11
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Liu, Zheng (2006-05-18)Department: Microbiology and ImmunologyAutoimmune and atopic diseases are immune-mediated multigenic diseases. The work of this thesis tests the hypothesis of performing gene expression profiling using peripheral blood mononuclear cells as a common source to ...
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Sammons, Morgan Andrew (2010-08-13)Department: Biological SciencesMyotonic dystrophy type 2 (DM2) is an autosomal dominant human disease caused by the expansion of a tetranucleotide repeat in the first intron of the ZNF9 gene. While multiple studies link nucleotide expansions such as ...
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Cisneros III, Alberto (2019-03-28)Department: Chemical and Physical BiologyThe FV region of an antibody consists of the heavy chain (HC) and light chain (LC) variable domains whose association is maintained by a series of conserved, non-polar interactions. During chronic infections, somatic ...
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Adams, Nicholas Morgan (2014-03-19)Department: Chemical and Physical BiologySimple and rapid methods for detecting RNA biomarkers from patient samples are especially desirable in settings with limited access to laboratory resources and trained personnel. The focus of this dissertation is on the ...
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Torres, Victor J (2004-12-12)Department: Microbiology and ImmunologyExperimental and epidemiological studies have suggested that the vacuolating cytotoxin (VacA) is an important H. pylori virulence factor that contributes to the development of peptic ulceration and gastric adenocarcinoma. ...
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Browne, Christopher Michael (2013-06-04)Department: BiochemistryThis dissertation focuses on the biochemical and genetic characterization of the protein-protein interaction in the budding yeast Saccharomyces cerevisiae between the cytosolic translation initiation guanine nucleotide ...
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Voss, Bradley Jacob (2016-03-24)Department: Microbiology and ImmunologyColonization of the human stomach with Helicobacter pylori is a risk factor for development of gastric cancer and peptic ulcer disease. Proteins present on the surface of H. pylori mediate adhesion to the host gastric ...
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Galassie, Allison Caitlin (2017-03-03)Department: ChemistryVaccines are one of the greatest public health successes; yet there is an incomplete understanding of which genes and proteins are induced by vaccines and how they contribute to the development of protective immune responses. ...
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Strnad, Jessica Ann (2018-11-19)Department: Microbiology and ImmunologyThe human adaptive immune system is mediated in part by B cells, which produce antibodies to protect the body from infection. Antibodies are protein molecules responsible for recognizing and binding pathogenic targets ...
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Stobart, Christopher Colin (2013-10-18)Department: Microbiology and ImmunologyCoronaviruses (CoV) are positive-strand RNA viruses that encode large replicase polyproteins that are processed by two or three viral proteases to yield intermediate and mature nonstructural proteins (nsps). Nsp5 (3CLpro, ...
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Wogsland, Cara Ellen (2017-06-19)Department: Microbiology and ImmunologyB cells play a crucial role in adaptive immunity. They perform a multitude of functions including antibody and cytokine production and antigen presentation. The human adaptive immune response would not function effectively ...