Browsing by Author "Antonis Rokas"
Now showing items 1-20 of 20
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Lawson, Sarah Page (2014-09-22)Department: Biological SciencesThis research utilizes aphids to address some of the emerging themes in social evolution. To begin to address these themes, I identified traits to measure sociality in aphids. I found that for the ecological and behavioural ...
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Eidem, Haley Rae (2018-04-10)Department: Biological SciencesPreterm birth (PTB), or birth before 37 completed weeks of gestation, is the leading cause of newborn death worldwide. Despite its toll on human lives and economies, however, our understanding of its pathogenesis and ...
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Characterization of Recent Evolutionary Signatures of Genetic Elements involved in Human Pregnancy Moon, Jiyun (2019-05-08)Department: Biological SciencesEutherian pregnancy is characterized by relatively prolonged gestation and early establishment of direct maternal-fetal contact. In order to support extended growth of a genetically distinct fetus, the maternal immune ...
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Sivley, Robert Michael (2018-01-22)Department: Biomedical InformaticsPatterns of genetic variation along the human genome provide insight into functional and evolutionary constraints on different loci. Quantifying these patterns of constraint improves our ability to identify functional ...
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Ortiz, Juan Felipe (2019-04-16)Department: Biological SciencesAnimal body plans, olfaction, immune response, and, neuronal connectivity, among many others, traits that in addition to being highly polymorphic, are driven by clusters of tandemly duplicated genes (CTDG). CTDGs are not ...
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Rao, Mahesh Badeti (2016-07-27)Department: Biological SciencesRetina damage or disease in humans often leads to reactive gliosis, preventing the formation of new cells and resulting in visual impairment or blindness. Currently, treatments are being developed to stimulate repair or ...
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Cha, Diana Jean (2017-04-14)Department: Biological SciencesThere is growing evidence for the regulatory roles of extracellular RNAs (exRNAs) in mediating cell-to-cell communication. To test whether exosomal RNA might also contribute to changes in gene expression in recipient cells, ...
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Rajaram, Kamya (2014-07-16)Department: Biological SciencesZebrafish spontaneously regenerate their retinas after a variety of retinal insults. Key to regeneration are resident support cells called Müller glia (MG), which respond to injury by reverting to a stem cell-like state ...
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Wei, Chunyao (2013-07-02)Department: Biological SciencesmicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by specific binding to recognition elements in the 3’ untranslated regions (UTRs) of target mRNAs. In zebrafish ...
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Robertson, James Brian (2009-09-01)Department: Biological SciencesThe yeast respiratory oscillation is a 3 to 5 hour biological rhythm in some strains of Saccharomyces cerevisiae that occurs under a specific range of growth conditions during continuous culture. The cell division cycle, ...
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Brucker, Robert Merrill (2013-04-15)Department: Biological SciencesSymbiosis is a process by which two or more distinct organisms interact, whereas speciation is the diversifying process by which one species splits into two. Symbiosis and speciation are not commonly discussed together and ...
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Lind, Abigail Lee (2014-11-14)Department: Biomedical InformaticsFilamentous fungi produce diverse secondary metabolites (SMs) essential to their ecology and adaptation. Although each SM is typically produced by only a handful of species, SM production is coordinated with developmental ...
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Lind, Abigail Lee (2017-07-20)Department: Biomedical InformaticsFilamentous fungi produce a diverse array of secondary metabolites (SMs) that play ecological roles in defense, virulence, and inter- and intra-species communication. Fungal SMs have both deleterious and beneficial impacts ...
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Gibbons, John Gregory (2012-06-29)Department: Biological SciencesThe genome is a dynamic system storing the genetic information responsible for the astounding diversity of life and examination of its variability is crucial to understanding the phenotypic differences between and within ...
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Funkhouser-Jones, Lisa Jean (2016-02-29)Department: Biological SciencesMaternally transmitted microbes that infect host germ cells are perfectly poised to influence animal genome evolution, either directly through horizontal gene transfer or indirectly through selection for host genetic ...
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League, Garrett Philip (2017-03-24)Department: Biological SciencesMosquitoes encounter pathogens throughout their holometabolous life cycle, be it in the microbe-rich pools of the aquatic larva stage or the infected blood meals of the terrestrial adult stage. Pathogens that invade the ...
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Brooks, Andrew Wallace (2019-05-15)Department: Human GeneticsGut microbiomes, the genetic repertoire for millions to trillions of microbes residing throughout each metazoan’s digestive tract, are shaped by their host and environment. Composed of up to 500 times the genetic diversity ...
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Birnbaum, Stephanie Sue Ling (2019-05-15)Department: Biological SciencesHerbivorous insects are among the most numerous and diverse group of eukaryotes described, and their intimate relationships with host plants provide unique and powerful models for understanding the molecular mechanisms ...
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Chen, Ling (2019-11-15)Department: Biological SciencesEnhancers are genomic regions distal to promoters that bind transcription factors (TFs) to regulate the dynamic spatiotemporal patterns of gene expression required for proper differentiation and development of multi-cellular ...
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EPUM, ESTHER AKUNNA (2019-09-16)Department: Biological SciencesDNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. In addition to maintaining telomeres, telomerase can act on DSBs creating de novo telomeres, a mutagenic ...