Browsing by Author "Ariel Deutch"
Now showing items 1-15 of 15
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Murphy, Monika Jill Magram (2018-03-29)Department: NeuroscienceThe prefrontal cortex (PFC) is most commonly defined as the frontal cortical area receiving a mediodorsal (MD) thalamic innervation, however other have put forth that the PFC in the zone of convergent innervation from the ...
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Ni, Mingwei (2011-11-23)Department: PharmacologyMercury accumulates in fish-eating populations. Glial cells have diverse functions including providing nutrition[1], maintaining CNS homeostasis, removing pathogens, inducing neuronal differentiation and mediating CNS ...
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Dadalko, Olga Igorevna (2015-11-19)Department: NeuroscienceDue to the escalating obesity epidemic in the United States, an important public health concern is the comorbidity of metabolic disorders and mental illness. Mounting clinical evidence supports the comorbid nature of mental ...
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Helmcke, Kirsten Jeanne (2010-01-18)Department: PharmacologyMethylmercury (MeHg), a known neurotoxicant, is found in seafood, leading to regular exposure of humans to this compound. Many of the molecular targets and detoxifying components of MeHg toxicity, including glutathione ...
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Couppis, Maria Helena (2008-02-26)Department: NeuroscienceDOPAMINE AND THE POSITIVELY REINFORCING PROPERTIES OF AGGRESSION MARIA H. COUPPIS Dissertation under the direction of Professor Craig H. Kennedy Aggression is a necessary behavioral response aimed at securing survival. ...
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Brown, Abigail Maureen (2007-07-31)Department: Molecular Physiology and BiophysicsMOLECULAR PHYSIOLOGY AND BIOPHYSICS DOPAMINE DEPLETION ALTERS THE BALANCE BETWEEN CA2+/CALMODULIN-DEPENDENT PROTEIN KINASE II AND PROTEIN PHOSPHATASE I ABIGAIL M. BROWN Dissertation under the direction of Professor ...
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Sillivan, Stephanie Elizabeth (2011-12-04)Department: NeuroscienceEmbryonic dopamine (DA) receptor (DR) expression in the medial frontal cortex (mFC) coincides with the formation of neural circuits during the period of axon pathfinding but the signaling properties of DRs and their effect ...
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Williams, Megan Ann (2015-07-20)Department: NeuroscienceThe dysfunction of dopamine signaling can contribute to mood disorders and drug abuse. Dopamine neurons do not belong to one homogenous group and differ in their electrophysiological properties and molecular expression ...
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Olaghere da Silva, Uade (2010-02-09)Department: NeuroscienceTranscripts encoding 5HT2C receptors are modified posttranscriptionally by RNA editing, generating up to 24 protein isoforms. In recombinant cells, the fully edited isoform, 5HT2C-VGV, exhibits blunted G-protein coupling ...
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Zike, Isaac Daniel (2017-05-26)Department: PharmacologyObsessive-compulsive disorder (OCD) is a chronic, disabling condition with inadequate treatment options that leave most patients with substantial residual symptoms. Structural, neurochemical, and behavioral findings point ...
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Shirey-Rice, Jana Kristin (2010-04-15)Department: PharmacologyMuscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 ...
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Johnson, Kari Anne (2013-04-15)Department: PharmacologyMetabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that play important roles in the modulation of neurotransmission in the central nervous system (CNS). The eight subtypes of mGluRs are differentially ...
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Joffe, Max Emanuel (2016-04-26)Department: PharmacologyDysregulation of the mesolimbic dopamine (DA) system is a hallmark of the pathophysiology of drug addiction and many other prevalent diseases. The nucleus accumbens (NAc), a region essential for the incentive and hedonic ...
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Klug, Jason Richard (2012-09-25)Department: NeuroscienceThe role of striatal Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the GluN2B subunit of the NMDA receptor in excitatory glutamatergic transmission, morphology and behavior are presented in this thesis. The ...
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Kusnoor, Sheila Vijay (2010-03-30)Department: NeuroscienceThe thalamic caudal intralaminar nuclear complex is composed of the centromedian-parafascicular (CM-PF) nuclei in primates and the PF in rodents. These thalamic neurons project to the striatum and synapse onto the dendritic ...