Browsing by Author "Benjamin Spiller"
Now showing items 1-10 of 10
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Shi, Rongxin (2018-06-11)Department: Biological SciencesDNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications. Bacterial HEAT-like repeat glycosylases AlkC and AlkD are specific for ...
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Breland, Erin Jenness (2017-08-02)Department: PharmacologyAntibiotic resistance in bacteria is increasing globally. Urinary tract infections, which account for the majority of antibiotic prescriptions, are primarily caused by uropathogenic E. coli (UPEC). The latest report by the ...
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Coffa, Sergio (2011-08-05)Department: PharmacologyArrestins are multifunctional signaling proteins, important for the regulation of signal transduction and the trafficking of G protein-coupled receptors (GPCRs). Recently, GPCR-arrestin interactions have been proposed to ...
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Willis, Jordan R (2014-06-12)Department: Chemical and Physical BiologyHuman antibodies are critical for eradication of viral and bacterial infections, while providing the basis for immunological memory. Antibody design using the molecular modeling suite Rosetta is used to answer questions ...
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Watkins, Guy Richard (2012-12-01)Department: PharmacologyStudies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...
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Aiyegbo, Mohammed Sefiu (2013-04-30)Department: Microbiology and ImmunologyPrevious human antibody studies have shown that the human VH1-46 antibody variable gene encodes much of the naturally-occurring human B cell response to rotavirus, and is directed to virus protein 6 (VP6). It is currently ...
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Germane, Katherine Lynn (2011-08-24)Department: Microbiology and ImmunologyVirulence effectors are a diverse group of proteins secreted by pathogenic bacteria to enable infection by concertedly acting to obstruct host defenses. A major step during invasion and spread for intracellular pathogens ...
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Wan, William Nicholas (2014-03-17)Department: Chemical and Physical BiologyPrions are infectious proteins; aberrantly folded proteins with self-propagating structures that induce a biological effect. Prions are implicated in a number of diseases, including the transmissi- ble spongiform ...
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LeNoue-Newton, Michele Laura (2015-11-27)Department: PharmacologyAlpha4 is multi-domain protein with a structured N-terminal region that binds to PP2A family catalytic subunits and an unstructured C-terminal domain that binds to E3-ubiquitin ligases. Unlike typical regulatory subunits ...
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Bokiej, Magdalena (2012-08-21)Department: Microbiology and ImmunologyThis dissertation research was focused on elucidating mechanisms at the reovirus-host interface that allow successful completion of the initial replicative steps and lead to viral protein synthesis. During the course of ...