Browsing by Author "Bingshan Li"
Now showing items 1-11 of 11
-
Moore, Carrie Colleen Buchanan (2013-12-05)Department: Human GeneticsMany recent studies have identified rare variants that contribute to common, complex disease. It is believed that rare variants likely have a larger effect size (compared to GWAS findings) and can act alone, in concert ...
-
Bray, Michael Joseph (2018-03-20)Department: Human GeneticsUterine fibroids, benign tumors of the uterus, are the most common female pelvic tumor. Fibroids are highly heterogeneous, with some women developing a single small fibroid while other women develop multiple and/or large ...
-
D'Aoust, Laura Nicole (2015-03-27)Department: Human GeneticsAlzheimer disease (AD) is the most common cause of dementia. As with many complex diseases, the identified variants do not explain the total expected genetic risk that is based on heritability estimates for AD. Isolated ...
-
Cummings, Anna Christine (2012-12-07)Department: Human GeneticsLate-onset Alzheimer disease (LOAD) is a complex neurodegenerative disorder with a strong genetic component. APOE is a well-established risk gene for LOAD, and several other genes have also been identified. However, at ...
-
Zeng, Chenjie (2017-11-21)Department: EpidemiologyPrevious pharmacogenetics studies of 5-fluorouracil (5-FU) have focused on coding variants, and only four of these variants showed consistent association, which explained a small fraction of the heritability of 5-FU-associated ...
-
White, Marquitta Jonisse (2014-08-28)Department: Human GeneticsCardiovascular disease (CVD) is an inclusive term encompassing several disorders of the circulatory system that together account for the majority of global non-communicable disease (NCD) mortality. Major thrombotic events, ...
-
Sobota, Rafal Sebastian (2015-04-13)Department: Human GeneticsOne third of the world’s population has been infected with Mycobacterium tuberculosis (MTB). Most of those exposed develop an asymptomatic latent infection. In the absence of co-morbidities, only 5-10% of people progress ...
-
Restrepo, Nicole Ann (2015-03-23)Department: Human GeneticsCommon age, related eye diseases are a major driving force behind vision disability and blindness. The three most common diseases afflicting Americans today are age-related macular degeneration (AMD), primary open-angle ...
-
Giri, Ayush (2015-11-02)Department: EpidemiologyPelvic organ prolapse (POP) is characterized by the descent of pelvic organs (uterus, bladder, and bowels) from their normal anatomical positions into the vaginal space due to defects in the pelvic floor support system. ...
-
Han, Mi-Ryung (2016-03-20)Department: EpidemiologyTo date, common genetic variants in ~ 109 loci have been identified for breast cancer risk via genome-wide association studies (GWAS). Most common variants found in GWAS are located in non-coding region, thus impeding the ...
-
Levinson, Rebecca Terrall (2016-11-21)Department: Human GeneticsWhile genetic association studies have been able to elucidate the importance of genetics in human disease outcomes, these studies are limited by the necessity of collecting specifically tailored cohorts and that they ...