Browsing by Author "Brandt F. Eichman"
Now showing items 1-15 of 15
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Weiner, Brian Edward (2008-07-28)Department: BiochemistryThe replication of DNA occurs through a complex series of steps involving the coordinated action of many proteins. DNA polymerase alpha/primase (pol-prim) is a critical DNA replication factor that synthesizes short RNA-DNA ...
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Shi, Rongxin (2018-06-11)Department: Biological SciencesDNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications. Bacterial HEAT-like repeat glycosylases AlkC and AlkD are specific for ...
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Holt, Marilyn Elaine (2019-02-12)Department: Chemical and Physical BiologyReplication of our genes requires unwinding of DNA and generating the new complementary strands for both leading and lagging parental strands. The DNA polymerases that generate the complementary strands require a short ...
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Chumbler, Nicole Marie (2015-03-26)Department: Chemical and Physical BiologyClostridium difficile is a common nosocomial infection that encompasses a range of clinical symptoms from mild diarrhea to complicated pseudomembranous and fulminant colitis. C. difficile secretes two large toxins, TcdA ...
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Huang, Hao (2010-11-30)Department: Biological SciencesDNA polymerase ¦Á-primase (pol-prim) plays a central role in eukaryotic DNA replication, initiating synthesis on both the leading and lagging strand DNA templates. Pol-prim consists of a primase heterodimer that synthesizes ...
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Jones, Patrick Leo (2013-11-18)Department: Biological SciencesThis dissertation is concerned with the expression patterns, functionality and mechanisms of disease vector mosquito odorant receptors. The principal afrotropical vector for malaria, Anopheles gambiae, discriminates human ...
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Warren, Garrett M (2019-05-15)Department: Biological SciencesDuring DNA replication the replication fork can become stalled by impediments that prevent complete and accurate duplication of the genome. DNA replication fork reversal is an important pathway for the protection and ...
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Couch, Frank Benjamin IV (2014-04-17)Department: BiochemistryErrors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
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Chavez, Diana Andrea (2018-06-26)Department: Biological SciencesDuring DNA replication, a moving replication fork can encounter various sources of replication stress that can lead the moving fork to stall. Organisms have developed various DNA damage response pathways that recruit and ...
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Frazier, Meredith N. (2018-03-26)Department: Biological SciencesThe adaptor protein 4 (AP4) heterotetrameric complex helps form vesicles and traffic cargo from the trans-Golgi Network. Tepsin, a member of the epsin family of trafficking proteins, is the only known accessory protein of ...
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Borin, Brendan Nathaniel (2008-12-30)Department: Biological SciencesStructural, biological, and phenotypic analyses of proteins that are involved in transcriptional regulation in the pathogenic bacterium Helicobacter pylori are presented. A high-resolution structure of the C-terminal ...
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Robertson, Patrick David (2010-06-04)Department: Biological SciencesEukaryotic DNA replication is tightly regulated during the initiation phase to ensure that the genome is copied only once and at the proper time during each cell cycle. During replication initiation, over twenty different ...
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Xu, Wen (2008-12-01)Department: ChemistryThis dissertation involved the structural investigations of butadiene-derived N6,N6-deoxycytosine intrastrand cross-linked adduct and N3-deoxyuridine adducts in DNA by NMR or X-ray crystallography, respectively. Solution ...
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Millsap, Amy Danae (2015-11-30)Department: Chemistry2-Amino-3-methylimidizo-[4,5-ʄ]-quinoline (IQ), a potent dietary mutagen, forms DNA adducts at the N² and C8-positions of 2ʹ-deoxyguanosine. IQ induces G to A transitions and G to T transversions in eukaryotic cells. The ...
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Collier, Scott Edward (2015-05-27)Department: Cell and Developmental BiologyThe spliceosome is a dynamic macromolecular machine composed of five different small nuclear ribonucleoproteins (snRNPs), the Nineteen Complex (NTC), RNA helicases, and other proteins that catalyze the removal of introns ...