Browsing by Author "Brian Wadzinski"
Now showing items 1-14 of 14
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Mazalouskas, Matthew David (2014-04-14)Department: PharmacologyThe macromolecular assembly of protein serine/threonine phosphatase•kinase complexes mechanistically enhances the speed and fidelity of cell signaling events. These signaling modules allow for acute regulation of substrates ...
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Moore-Lotridge, Stephanie Nicole (2018-11-20)Department: PharmacologyCalcium and phosphate are essential elements in many biological processes, such as basic cellular function and signaling, yet they also combined to make biological crystals, most notably hydroxyapatite found in bone. ...
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Bryant, Nora Kayton (2015-10-20)Department: Molecular Physiology and BiophysicsDiabetes is characterized by excess levels of glucose and lipid in the blood, which have been proposed to directly and negatively impact islet β cells, exacerbating symptoms and promoting disease progression. Our understanding ...
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Sprinkel, Katie Connors (2016-04-08)Department: Interdisciplinary Studies: Analytical PharmacologyEicosanoids, such as prostaglandins, leukotrienes, hydroxy- and epoxy-derivatives of arachidonic acid (AA), are lipid autacoids that regulate constitutive as well as inflammatory processes. Prostaglandins (PGs) and ...
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Broadus, Matthew Ryan (2013-04-17)Department: Cell and Developmental BiologyThe Cdc14 phosphatase family antagonizes Cdk1 phosphorylation and is important for mitotic exit. Dynamic localization is a major means of regulating this phosphatase family, yet how localization changes occur, or how ...
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Reiner, Jennifer Elisabeth (2011-06-30)Department: Cancer BiologyThe serine threonine kinase receptor-associated protein (STRAP) is a WD40 domain protein that regulates a wide array of biological processes. Previous reports suggest that STRAP possesses oncogenic characteristics and ...
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Thiel, William Howard (2008-12-02)Department: PharmacologyCa2+ activated signaling pathways coordinate contraction in the heart, but these pathways cause disease upon excessive activation. Intracellular Ca2+ activates the multifunctional Ca2+ and calmodulin dependent protein ...
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Wolfe, Benjamin (2005-04-20)Department: Cell and Developmental BiologyProgression through the eukaryotic cell cycle involves the coordinated activation and inactivation of cyclin dependent kinases. One such family member, Cdk1p in a complex with Cyclin B, is activated at the G2/M transition ...
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Watkins, Guy Richard (2012-12-01)Department: PharmacologyStudies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...
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Goodwin, Craig Matthew (2015-11-24)Department: PharmacologyMalignant cancers are the second leading cause of death in the United States, with a projected 1.6 million new diagnoses per year and almost 600,000 deaths. Our understanding of the molecular pathways causing tumor initiation, ...
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LeNoue-Newton, Michele Laura (2015-11-27)Department: PharmacologyAlpha4 is multi-domain protein with a structured N-terminal region that binds to PP2A family catalytic subunits and an unstructured C-terminal domain that binds to E3-ubiquitin ligases. Unlike typical regulatory subunits ...
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Speed, Nicole Kathryn (2010-08-04)Department: PharmacologyDopaminergic neurotransmission is a critical component in the regulation of several behaviors, including cognition, motor function, motivation, and reward. Abnormalities in dopamine (DA) signaling have been linked to ...
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Chen, Qiuyan (2015-11-24)Department: PharmacologyArrestin selectively binds the phosphorylated active receptor to either terminate the G protein dependent signaling or initiate G protein independent signaling. Receptor binding induces global conformational changes in ...
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Gruver, Jonathan Scott (2010-02-16)Department: PharmacologyCell motility plays important roles in development, wound healing, and metastasis. Cells move either spontaneously, in a non-directed fashion, or in response to chemotactic signals, in a directed fashion. Even though they ...