Browsing by Author "Bruce Appel"
Now showing items 1-15 of 15
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Pan, Luyuan (2007-12-17)Department: Biological SciencesFragile X Syndrome (FXS) is the most common form of inherited mental retardation. In this thesis, I describe my work using a Drosophila model to study cellular, molecular and genetic mechanisms that underlie the cognitive ...
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Roberts, Randolph K. (2009-07-19)Department: Biological SciencesDuring spinal cord development, precursor cells transition from proliferative divisions to differentiative divisions. Traditionally proliferative divisions, which increase cell numbers, are thought to be symmetric, whereas ...
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Ripley, Anna Nesset (2004-03-29)Department: Cell and Developmental BiologyI will introduce two novel genes isolated by my laboratory, hole and bves. This document will show that the benefits of gene discovery are invaluable. Bves, a novel family of cell adhesion molecules have been identified ...
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Flynt, Alex Sutton (2007-12-04)Department: Biological SciencesIn recent years it has become apparent that microRNAs (miRNAs) are common feature of eukaryotic genomes. The functional products of these non-canonical genes are small, ~22nt RNAs that negatively regulate translation. ...
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Essential Roles of Convergence and Extension Gastrulation Movements in Zebrafish Somite Development Yin, Chunyue (2007-02-27)Department: Biological SciencesDuring vertebrate gastrulation, massive cell movements shape the basic body plan. Key components of gastrulation are convergence and extension (C&E) movements, which narrow and lengthen the embryonic tissues, respectively. ...
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Fox, Rebecca Marie (2006-12-01)Department: Cell and Developmental BiologyAnimal movement is controlled by the motor circuit, which features an axial nerve cord where motor neurons transmit signals from the brain to specific muscles. The development of this circuit depends on differential gene ...
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Snyder, Julia Lynn (2013-07-29)Department: Biological SciencesDissertation under the direction of Professor Bruce H. Appel Oligodendrocytes are specialized glial cells in the vertebrate central nervous system (CNS) that extend processes to wrap axons in myelin sheaths. Their number ...
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Watson, Joseph Daniel (2007-07-30)Department: NeuroscienceIn order to form synaptic connections, an individual neuron needs to coordinate the activities of a large number of proteins. The neuron can modulate the activity of these proteins in a variety of ways. For instance, ...
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Kosinski, Mary E. (2005-07-18)Department: Cell and Development BiologyFertilization is a complex process involving several steps, including sperm activation, oocyte maturation, chemotaxis, gamete recognition, and cell fusion. Many of these essential steps are controlled and regulated by ...
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Sarangi, Anuraag (2009-09-29)Department: NeuroscienceGliomas are the predominant type of primary central nervous system tumors. They are highly invasive and notoriously refractory to current therapies. Patients diagnosed with a malignant glioma face a dismal prognosis that ...
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Xia, Yuanfeng (2008-11-10)Department: Biological SciencesThis thesis is concerned with the study of olfactory systems in both larval and adult mosquitoes. In this dissertation I cloned the first odorant receptor from mosquito Culex quinquefasciatus and localized the receptor ...
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Zannino, Denise Allison (2009-04-01)Department: NeuroscienceIn the spinal cord, most oligodendrocytes, the myelinating cell type of the CNS, and motor neurons arise from common, ventral, olig2-expressing precursors called pMN cells. In the hindbrain, the degree to which motor neurons ...
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Speirs, Christina Koo Yang (2009-09-11)Department: Biological SciencesProstaglandin E2 (PGE2) influences many processes in vertebrates, including development, homeostasis, and disease through its GPCRs EP receptors 1-4. PGE2 regulates gastrulation movements during zebrafish embryogenesis, ...
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Earls, Laurie Rebecca (2007-12-13)Department: Cell and Developmental BiologyDissertation under the direction of Professor David M. Miller III Impairment of neurons expressing the neurotransmitter ?-amminobutyric acid (GABA) can result in psychiatric diseases as diverse as schizophrenia, epilepsy, ...
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Chopra, Sameer (2008-12-06)Department: PharmacologyElectrical signaling events are required for each human thought, feeling, and perception, the movement of our limbs, and the beat of our hearts. As the initiators of action potentials in excitable tissues, voltage-gated ...