Browsing by Author "Carmelo J. Rizzo"
Now showing items 1-11 of 11
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Birmingham, William Ross (2013-12-03)Department: BiochemistryEngineered biocatalysts have become increasingly sought after as replacements for individual chemical synthetic steps. However, their implementation in multistep sequences as biosynthetic pathways has proven to be a ...
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Hong, Ki Bum (2010-04-07)Department: ChemistryThe vicinal aminoalcohol moiety is a common structural motif in various groups of natural products, pharmaceuticals, ligands for metals, and chiral auxiliaries. A variety of synthetic molecules containing 1,2-aminoalcohols ...
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Durbin, Braden Michael (2015-02-23)Department: ChemistryOne family of platforms to probe molecular interactions utilizes interferometry. Interferometry has a major advantage over other techniques in that it does not require the use of labels, which could affect interactions ...
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Garmendia, Craig Alexander (2008-12-15)Department: ChemistryExposure to endogenous and exogenous chemicals can lead to modification of DNA and potentially lead to cancer. Frameshift mutations may be a consequence of these modifications to DNA. Oligonucleotides were synthesized ...
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Mathew, Priya Ann (2012-07-27)Department: ChemistryMitomycin C is a clinically used antitumor natural product isolated from <i>Streptomyces caespitosus</i>. The biological activity and synthetic challenge of mitomycin C has generated broad interest in its chemical synthesis. ...
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Braun, Caroline Mary (2018-04-09)Department: ChemistryOligosaccharides and glycoconjugates are important for understanding biological functions. A major obstacle in glycobiology and glycomedicine is the limited availability of structurally-defined, homogeneous oligosaccharides ...
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Xu, Wen (2008-12-01)Department: ChemistryThis dissertation involved the structural investigations of butadiene-derived N6,N6-deoxycytosine intrastrand cross-linked adduct and N3-deoxyuridine adducts in DNA by NMR or X-ray crystallography, respectively. Solution ...
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Bowen, Ryan Scott (2016-03-25)Department: ChemistryN6-(Deoxy-D-Erythro-Pentofuranosyl)-2,6-Diamino-3,4-Dihydro-4-Oxo-5-N-Methylformamido-Pyrimidine (MeFapy-dG) is a deoxyribonucleic acid lesion that has been hypothesized to be induced by methylating chemotherapeutic agents. ...
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Dempster, Richard Kenichi (2014-12-24)Department: ChemistryN6-(Deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dG) is the methylated and persistent ring opened product of the common N7 alkylation site of guanines in DNA, formed ...
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Kuo, Dennis W. (2015-11-27)Department: Chemical and Physical BiologyChemical and Physical Biology Structures of the 3,4-Epoxybutene-Derived R- and S-N1-(2-Hydroxy-buten-2-yl) -2' Deoxyinosine DNA Adducts: Regiochemical Control of Glycosidic Torsion Angle Conformation Dennis Kuo Thesis ...
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Rigsby, Rachel Pharris (2005-07-15)Department: ChemistryCHEMISTRY STUDIES OF A GENOMIC FOSFOMYCIN RESISTANCE PROTEIN FROM PSEUDOMONAS AERUGINOSA RACHEL PHARRIS RIGSBY Dissertation under the direction of Professor Richard N. Armstrong In the last two decades it has become ...