Browsing by Author "Carmelo Rizzo"
Now showing items 1-10 of 10
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Brooks, Sonja Claudia (2014-06-25)Department: Chemical and Physical BiologyThe methylation state of DNA is important for gene expression, gene imprinting, X-chromosome inactivation, and transposon silencing in mammals and plants. DNA methylation is established by methyltransferases to mark a ...
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Whitley, Brent Tyler (2013-04-16)Department: ChemistryAflatoxin B1 (AFB1), a carcinogenic mycotoxin produced by the common agricultural contaminant A. flavus, has been implicated in the high rates of hepatocellular carcinoma observed in some developing countries. Upon ...
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Shi, Rongxin (2018-06-11)Department: Biological SciencesDNA glycosylases preserve genome integrity and define the specificity of the base excision repair pathway for discreet, detrimental modifications. Bacterial HEAT-like repeat glycosylases AlkC and AlkD are specific for ...
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Petrovic, Ana Grozdan (2007-08-17)Department: ChemistryThe significance of being able to reliably establish the structure of chiral molecules is manifested through the recognition that different enantiomers and diastereomers of the same compound can have vastly different effects ...
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Stavros, Kallie Marie (2015-02-26)Department: Chemical and Physical Biology2-Amino-3-methylimidazo-[4,5-f]quinoline, IQ, has been identified as one of the most genotoxic materials according to Ames assays and animal studies. IQ is during high temperature cooking of meats and is classified as ...
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Collins, Nina Renee (2013-07-29)Department: ChemistryThe furanocembranoids are a family of natural products generated from oxidation and polycyclization of well-established terpene frameworks. The biosynthesis of these metabolites involves oxidative installation of butenolide ...
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Szulik, Marta Wieslawa (2014-04-16)Department: ChemistryThe search for active demethylation processes lead to discovery of 5-hydroxymethylcytosine (5hmC) adduct in the mammalian DNA. This lesion is formed post-replicatively by oxidation of ...
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Kowal, Ewa Anna (2012-12-17)Department: ChemistryTo examine the effect of major groove electrostatics on the stability and structure of DNA, in the first portion of this dissertation a detailed structural characterization of the 7-deaza-2'-deoxyadenosine:dT base pair in ...
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Christov, Plamen Petkov (2007-10-08)Department: ChemistryMethylating agents react with DNA to give the cationic N7-methyl deoxyguanosine adduct, which can undergo hydrolytic opening of the imidazole ring to form 2,6-diamino-4-hydroxy-N5-(methyl)-formamido-pyrimidine (MeFAPy-dGuo) ...
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Gerding, Jason Scott (2015-03-30)Department: ChemistryThe scope of this thesis is focused on the development and characterization of paramagnetic bent-core liquid crystals based on the verdazyl radical. Intermediary to both crystalline and ordinary liquid states of matter ...