Browsing by Author "Charles R. Sanders"
Now showing items 1-14 of 14
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Holt, Marilyn Elaine (2019-02-12)Department: Chemical and Physical BiologyReplication of our genes requires unwinding of DNA and generating the new complementary strands for both leading and lagging parental strands. The DNA polymerases that generate the complementary strands require a short ...
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Saban, Susan Dora (2006-11-01)Department: Molecular Physiology and BiophysicsAdenovirus (Ad) vectors are promising vehicles for vaccine delivery and gene therapy, but vector development has been hampered by the lack of an atomic structure of the intact virion. In this work, cryoEM single particle ...
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Kim, Sunghoon (2011-12-08)Department: Chemical and Physical BiologyThe adaptor protein ankyrin-R interacts via its membrane binding domain with the cytoplasmic domain of the anion exchange protein (AE1) and via its spectrin binding domain with the spectrin based membrane skeleton in human ...
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McClendon, Amy Kathleen (2006-04-12)Department: BiochemistryHUMAN TOPOISOMERASES AND DNA GEOMETRY: PUTTING A POSITIVE TWIST ON ENZYME ACTION AMY KATHLEEN MCCLENDON Topoisomerases play critical roles in maintaining DNA topology during cellular processes such as DNA replication ...
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Xia, Yan (2018-07-11)Department: Chemical and Physical BiologyStructure elucidation for large membrane proteins remains a challenging task. As membrane protein structure determination is entering another stage of probing the ensemble of dynamic structures, methods such as NMR, EPR ...
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Mushrush, Darren J (2011-09-06)Department: BiochemistryBotulinum neurotoxin (BoNT) belongs to a large class of toxic proteins that act by enzymatically modifying cytosolic substrates within eukaryotic cells. The process by which a catalytic moiety is transferred across a ...
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Hankins, Hannah Marcille (2016-04-19)Department: Biological SciencesWithin a eukaryotic cell is a steady stream of vesicles budding from and fusing to different membranes to generate distinct organelles. The formation and movement of these vesicles is a complicated and interconnected process ...
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Hutton, Josiah Ewing III (2016-11-15)Department: BiochemistryBIOCHEMISTRY Oncogenic KRAS and BRAF Drive Metabolic Reprogramming in Colorectal Cancer Josiah Ewing Hutton, III. Dissertation under the direction of Professor Daniel C. Liebler Analysis of cancer cells that have ...
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Zhou, Xiaoming (2010-03-19)Department: Biological SciencesType-IV P-type ATPases are putative phospholipid flippases that translocate specific phospholipid substrates from the exofacial to the cytosolic leaflet of membranes to generate phospholipid asymmetry. However, flippase ...
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Frazier, Meredith N. (2018-03-26)Department: Biological SciencesThe adaptor protein 4 (AP4) heterotetrameric complex helps form vesicles and traffic cargo from the trans-Golgi Network. Tepsin, a member of the epsin family of trafficking proteins, is the only known accessory protein of ...
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Borin, Brendan Nathaniel (2008-12-30)Department: Biological SciencesStructural, biological, and phenotypic analyses of proteins that are involved in transcriptional regulation in the pathogenic bacterium Helicobacter pylori are presented. A high-resolution structure of the C-terminal ...
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Claxton, Derek Paul (2010-08-02)Department: Molecular Physiology and BiophysicsRe-uptake of neurotransmitters through membrane-bound transport proteins is the primary mechanism of terminating synaptic transmission in the central nervous system. Biogenic monoamine transporters couple the movement of ...
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Chen, Qiuyan (2015-11-24)Department: PharmacologyArrestin selectively binds the phosphorylated active receptor to either terminate the G protein dependent signaling or initiate G protein independent signaling. Receptor binding induces global conformational changes in ...
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Mazerik, Jessica Nicole (2013-05-09)Department: Cell and Developmental BiologyEpithelial cells called enterocytes line the lumen of the small intestine and are responsible for nutrient processing and barrier maintenance. Enterocytes have highly ordered actin arrays, or brush borders, on their apical ...