Browsing by Author "Charles Sanders"
Now showing items 1-20 of 23
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Thiel, Kristina Wyatt (2007-10-03)Department: BiochemistryThe ErbB family of receptor tyrosine kinases regulates cell growth, differentiation, and tumorigenesis. This dissertation contains two independent studies of ErbB-1 and ErbB-4. In one study, the intracellular juxtamembrane ...
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Karakaş, Mert (2011-12-09)Department: Chemical and Physical BiologyStructural information facilitates understanding of protein function and activity. The limitations of experimental methods for protein structure elucidation in applicability to certain types and families of proteins, ...
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Dimitrova, Yoana Nantcheva (2010-10-29)Department: BiochemistryThe mechanism controlling the switch between gene activation and repression is critically important for understanding the process of transcriptional regulation. Gene expression is highly controlled through a dynamic exchange ...
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Deatherage, Catherine Laura (2016-03-29)Department: BiochemistryBIOCHEMISTRY Comparative Biochemical and Structural Analysis of the Alzheimer’s Disease Related Proteins: Amyloid Precursor Protein and Notch 1. Catherine Laura Deatherage Dissertation under the direction of Professor ...
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Stavros, Kallie Marie (2015-02-26)Department: Chemical and Physical Biology2-Amino-3-methylimidazo-[4,5-f]quinoline, IQ, has been identified as one of the most genotoxic materials according to Ames assays and animal studies. IQ is during high temperature cooking of meats and is classified as ...
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Lindert, Steffen (2011-03-14)Department: Chemical and Physical BiologyIn the course of this dissertation a software EM-Fold was developed that combines de-novo protein structure prediction and medium resolution cryoEM density maps. It can be applied to proteins containing α-helices and ...
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Sun, Qi (2015-04-20)Department: BiochemistryRas is a small GTPase that functions as a molecular switch, cycling between inactive (GDP-bound) and active (GTP-bound) states. Mutations in Ras fix the protein in the active state and endow tumor cells with the ability ...
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Perry, Evan Thomas (2019-03-15)Department: BiochemistryCTLA-4 and PD-1 are immune checkpoints that inhibit T cell activity to maintain immune homeostasis. These checkpoints have also emerged as highly validated cancer targets to stimulate immune responses against cancer. Despite ...
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Vann, Kendra Raychell (2016-04-05)Department: BiochemistryTopoisomerase II plays many essential roles in genome maintenance. To carry out its physiological functions, the enzyme generates transient double-stranded breaks in the DNA to help resolve topological problems that occur ...
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Keigher, Laura Elizabeth (2012-12-03)Department: Chemical and Physical BiologyiASPP (inhibitory member of the apoptosis stimulating protein of p53 family) is known to inhibit the important tumor suppressors p53 and p73. Indeed, iASPP is over-expressed in several cancer types and is associated with ...
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Brosey, Chris Arlen (2011-10-31)Department: BiochemistryThe integrity and propagation of the genome depends upon the fidelity of DNA processing events such as replication, damage recognition, and repair. Requisite to the numerous biochemical tasks required for DNA processing ...
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Thaker, Tarjani Mahesh (2013-12-09)Department: BiochemistryThe G protein coupled receptor (GPCR) family is comprised of ubiquitous, membrane-bound proteins that are highly conserved in structure, yet varied in their cognate ligand. This allows for regulation of diverse physiological ...
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Shah, Vikas N. (2005-08-12)Department: BiochemistryThe function of the human cardiac voltage-gated sodium channel hH1 is regulated in part by an EF-hand in its C-terminal cytoplasmic domain. The binding of calcium to the EF-hand results in calmodulin-independent, ...
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Leman, Julia Koehler (2012-07-23)Department: Chemical and Physical BiologyMembrane protein structures are very difficult to determine by solution NMR since severe line-broadening obstructs the measurement of restraints. To alleviate this problem we describe the measurement of paramagnetic ...
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Coffa, Sergio (2011-08-05)Department: PharmacologyArrestins are multifunctional signaling proteins, important for the regulation of signal transduction and the trafficking of G protein-coupled receptors (GPCRs). Recently, GPCR-arrestin interactions have been proposed to ...
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DeLuca, Stephanie Judith Han Hirst (2015-03-25)Department: Chemical and Physical BiologyMembrane proteins remain a particular challenge in structural biology. Only approximately 1.5% of reported tertiary structures and around 100 unique polytopic membrane proteins are represented in the Protein Data Bank ...
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Wenke, Jamie Lyn (2016-02-29)Department: BiochemistryThe ocular lens is a transparent optical element that focuses light onto the retina for clear vision. The bulk of the lens is composed of elongated, anuclear fiber cells, which are continuously synthesized throughout life ...
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Barrett, Paul John (2013-09-23)Department: BiochemistryBiochemistry Structural and Cholesterol Binding Properties of the Amyloid Precursor Protein C-Terminal Fragment C99 and the Etiology of Alzheimer’s Disease Paul John Barrett Dissertation under the direction of Professor ...
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Starbird, Chrystal Ama Rhea (2017-08-01)Department: Chemical and Physical BiologyThe long-term goal of this study is to evaluate key changes that occurred as a result of evolution from bacteria to the human respiratory enzyme, Complex II. Complex II has been extensively studied to define its roles in ...
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Ketron, Adam Christopher (2013-04-15)Department: Chemical and Physical BiologyThe topological structure of DNA is regulated by ubiquitous enzymes called topoisomerases. Type II topoisomerases resolve supercoils and remove knots and tangles from the genetic material by generating transient breaks in ...