Browsing by Author "Chris Aiken"
Now showing items 1-5 of 5
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Martin, Kenneth LaMont (2011-07-29)Department: Microbiology and ImmunologyAPOBEC3G (A3G) is a cytidine deaminase that inhibits the replication of human immunodeficiency virus type 1 (HIV-1) in the absence of the HIV-1 virion infectivity factor (Vif) protein. However, in the presence of the viral ...
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Lindquist, Michael Edward (2011-02-15)Department: Microbiology and ImmunologySeveral viruses are known to induce stress granules (SGs), however, a role for these structures during viral infection remains unknown. We first showed that respiratory syncytial virus (RSV) induces SGs starting approximately ...
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Willis, Jordan R (2014-06-12)Department: Chemical and Physical BiologyHuman antibodies are critical for eradication of viral and bacterial infections, while providing the basis for immunological memory. Antibody design using the molecular modeling suite Rosetta is used to answer questions ...
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Vetter, Michael L. (2009-03-31)Department: Microbiology and ImmunologyApolipoprotein B mRNA-editing complex 3G and 3F (APOBEC3G, A3G, A3F) reduce endogenous retrotransposition and also limit the replication of HIV-1. These cytidine deaminases have anti-HIV activity when packaged into virions, ...
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Yufenyuy, Ernest Limnyuy (2013-04-23)Department: Microbiology and ImmunologyThis dissertation discusses the role of intersubunit interfaces in HIV-1 capsid assembly and stability. In this study I showed the presence of both the NTD-CTD and CTD-CTD trimer interfaces in mature HIV-1 virions using ...