Browsing by Author "Christopher Aiken"

Now showing items 1-15 of 15

    • Analysis of Papain-like Protease Mediated Processing and Roles of the Cleavage Products in Coronavirus Replication 
      Gadlage, Mark Jacob (2010-03-02)
      Department: Microbiology and Immunology
      Coronaviruses belong to a family of enveloped, positive-strand RNA viruses that cause a multitude of devastating diseases in both animals and humans. Like other positive-strand RNA viruses, coronaviruses utilize several ...
    • Breaking in: human metapneumovirus fusion and entry 
      Cox, Reagan Josephine Greene (2012-12-07)
      Department: Microbiology and Immunology
      This project is concerned with how the recently discovered paramyxovirus, human metapneumovirus (HMPV), interacts with host cells to initiate entry. In this dissertation I explore whether the HMPV fusion protein interacts ...
    • HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus 
      Carnes, Stephanie Kaye (2019-03-20)
      Department: Microbiology and Immunology
      HIV-1 infection depends on efficient intracytoplasmic transport of the incoming viral core to the target cell nucleus. Evidence suggests that this movement is facilitated by the microtubule motor dynein, a large multi-protein ...
    • Identification of Novel Determinants of HIV-1 Uncoating in the Capsid Protein 
      Yang, Ruifeng (2009-02-10)
      Department: Microbiology and Immunology
      Uncoating of the viral core following penetration into the target cell represents a fundamentally obscure step in the HIV-1 life cycle. Our laboratory has previously reported that mutations in the CA protein that positively ...
    • Inhibitory Control of HIV-1 by Cyclophilin A 
      Burse, Mallori Jacole (2017-12-05)
      Department: Microbiology and Immunology
      The host protein cyclophilin A (CypA) can both stimulate and inhibit HIV-1 infection through its interaction with the viral capsid (CA). CypA enhances the early stages of HIV-1 infection in part by promoting nuclear import ...
    • Junctional Adhesion Molecule-A and Reovirus Pathogenesis 
      Antar, Annukka Aida Rose (2008-12-30)
      Department: Microbiology and Immunology
      Diverse families of viruses bind immunoglobulin superfamily (IgSF) proteins located in tight junctions and adherens junctions of epithelium and endothelium. However, little is known about the roles of these receptors in ...
    • MOLECULAR DETERMINANTS OF HUMAN ANTIBODY MEDIATED INHIBITION OF HUMAN NOROVIRUS 
      Alvarado, Gabriela S. (2019-03-12)
      Department: Microbiology and Immunology
      Human noroviruses (HuNoVs) are the leading cause of acute nonbacterial gastroenteritis and are responsible for 19-21 million cases of infection in the U.S. each year. There are currently no licensed vaccines, therapeutics, ...
    • Molecular Mechanisms Of HIV-1 Maturation And Host Factor Utilization 
      Anderson-Daniels, Jordan (2019-10-08)
      Department: Microbiology and Immunology
      HIV-1 is the major etiologic agent of AIDS, for which there is presently no cure or vaccine. The capsid is the structural component of HIV-1: it serves many functions during viral replication, and it is the product of ...
    • Molecular Mechanisms of Reovirus Capsid Assembly 
      Knowlton, Jonathan James (2018-07-12)
      Department: Microbiology and Immunology
      Protein folding encompasses the biological process by which a polypeptide achieves its functional three-dimensional conformation. Although some proteins can spontaneously reach their native shape, others cannot fold without ...
    • Post-entry Determinants of Mammalian Orthoreovirus Replication 
      Ooms, Laura Sue (2012-07-26)
      Department: Pathology
      Coordination of viral replication requires successful and often complex interactions of viral proteins and cellular factors. Although much progress has been made in understanding the formation of specialized sites of ...
    • Structural and functional determinants of effective CD8+ T cell suppression of HIV-1 replication 
      Simons, Brenna Colleen (2009-03-28)
      Department: Microbiology and Immunology
      CD8+ T cells are a critical component of an HIV-specific immune response. Our studies aimed to define the T cell receptor (TCR) structural determinants as well as effector functions associated with CD8+ T cell suppression ...
    • Structure-function analysis of mammalian orthoreovirus attachment protein ó1 
      Guglielmi, Kristen Marie (2008-04-04)
      Department: Microbiology and Immunology
      To efficiently initiate infection in target cells, viruses must become tethered to the plasma membrane by engaging cellular receptors. As the first step in the viral replication cycle, attachment is a key determinant of ...
    • The role of RNA in the packaging APOBEC3G into human immunodeficiency virus type 1 particles 
      Burnett, Atuhani Seth (2008-02-11)
      Department: Microbiology and Immunology
      APOBEC3G is a cytidine deaminase that inhibits HIV replication at a post-entry step in replication. APOBEC3G must be incorporated into the virus particle during assembly in order to inhibit HIV during the next round of ...
    • The role of the respiratory syncytial virus fusion protein in viral filamentous assembly 
      Shaikh, Fyza Yusuf (2012-06-04)
      Department: Microbiology and Immunology
      Respiratory syncytial virus (RSV) is a single-stranded RNA virus in the Paramyxoviridae family that is a leading cause of pneumonia and bronchiolitis in infants and the elderly. RSV preferentially assembles and buds from ...
    • Viral and cellular determinants of reovirus-induced NF-kB activation and apoptosis 
      Hansberger, Mark William (2006-11-01)
      Department: Microbiology and Immunology
      Mammalian reoviruses serve as important models for studies of viral replication and pathogenesis. These viruses have been isolated from many mammalian species, including humans, and cause disease primarily in the very ...