Browsing by Author "Christopher Wright"

Now showing items 1-10 of 10

    • Bves function in epithelial movement during development 
      Ripley, Anna Nesset (2004-03-29)
      Department: Cell and Developmental Biology
      I will introduce two novel genes isolated by my laboratory, hole and bves. This document will show that the benefits of gene discovery are invaluable. Bves, a novel family of cell adhesion molecules have been identified ...
    • Cell autonomous and non-cell autonomous regulation of beta cell mass expansion 
      Plank, Jennifer Lynn (2011-12-10)
      Department: Cell and Developmental Biology
      Diabetes mellitus affects approximately 150 million people worldwide. This disease is characterized by hyperglycemia resulting from dysfunctional pancreatic beta cells. Current treatments for diabetics are inadequate because ...
    • Identification of a vesicle budding mechanism for the release of a meiotic maturation hormone from Caenorhabditis elegans 
      Kosinski, Mary E. (2005-07-18)
      Department: Cell and Development Biology
      Fertilization is a complex process involving several steps, including sperm activation, oocyte maturation, chemotaxis, gamete recognition, and cell fusion. Many of these essential steps are controlled and regulated by ...
    • Loss of p120ctn : its effect on cadherin levels, development, and tumor progression 
      Davis, Michael Alan (2005-04-08)
      Department: Cancer Biology
      p120 binds and is thought to regulate the cell-cell adhesion molecule E-cadherin. Experiments in a p120-deficient carcinoma cell line suggest a critical role for p120 in stabilizing E-cadherin. p120 downregulation occurs ...
    • NF-kappa B signaling and inflammasome activation in developing fetal lung macrophages 
      Stouch, Ashley Nicole (2014-12-31)
      Department: Cell and Developmental Biology
      Bronchopulmonary dysplasia is a life-threatening lung disease affecting low birth weight preterm infants. While the occurrence of BPD is correlated with chorioamnionitis, the origination and pathway of fetal lung inflammation ...
    • NF-κB interacts with SP3 to limit SP1-mediated FGF-10 expression in the developing fetal lung 
      Carver, Billy Joe (2013-09-18)
      Department: Cell and Developmental Biology
      Arrested lung development in preterm infants leads to bronchopulmonary dysplasia (BPD). Inflammation and NF-κB activation in the fetal lung inhibit airway morphogenesis and contribute to BPD. The mesenchymal growth factor ...
    • RSKy Business in the Mammary Gland 
      Ludwik, Katarzyna Anna (2018-04-11)
      Department: Pathology
      The family of ribosomal S6 Ser/Thr protein kinases (RSK) controls proliferation, viability and motility and, therefore, contributes to the etiology of numerous cancers, including breast. We found that RSK2 is an obligate ...
    • Tales of three signaling pathways: EGFR, TGFB, and WNT signaling in the GI tract 
      Tanksley, Jarred Paul (2013-07-29)
      Department: Cell and Developmental Biology
      My study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
    • Tbx2b is required for parapineal organogenesis 
      Snelson, Corey Deanne (2009-03-13)
      Department: Biological Sciences
      The existence of anatomical differences along the left-right (L-R) axis in the brain and visceral organs is an evolutionarily conserved feature of the vertebrate lineage. Although much is known about the molecular pathways ...
    • The role of NFATc1 in proximal tubule injury and repair 
      Langworthy, Melissa Marie (2008-04-14)
      Department: Cell and Developmental Biology
      Recovery from acute kidney injury (AKI) requires renal tubule cell regeneration. The population of cells that repair the damaged proximal tubule epithelial cells (PTC) has been proposed to be derived from an external ...