Browsing by Author "Dan Roden"
Now showing items 1-10 of 10
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Moore, Carrie Colleen Buchanan (2013-12-05)Department: Human GeneticsMany recent studies have identified rare variants that contribute to common, complex disease. It is believed that rare variants likely have a larger effect size (compared to GWAS findings) and can act alone, in concert ...
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Bennett, Jeffrey Scott (2013-06-17)Department: Human GeneticsA BIPHASIC ROLE FOR THE VOLTAGE-GATED SODIUM CHANNEL SCN5LAB IN CARDIAC DEVELOPMENT OF ZEBRAFISH JEFFREY S. BENNETT Dissertation under direction of Professor Dan M. Roden, M.D. Voltage-gated sodium channels (VGSCs) play ...
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Wiley, Laura Katherine (2016-03-28)Department: Human GeneticsPharmacogenomics offers one of the best use cases for widespread clinical implementation of genomic medicine, as variants tend to have moderate allele frequencies, many of the affected medications are relatively common, ...
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English, Brett Alan (2010-04-12)Department: PharmacologyAcetylcholine (ACh) was one of the first neurotransmitters discovered and has been implicated in regulating a number of physiologic processes within the CNS and the periphery. Cholinergically-mediated physiology requires ...
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Parikh, Shan S. (2018-05-21)Department: PharmacologyMutations in lamin A/C (LMNA) are the second most common contributor to genetic cases of dilated cardiomyopathy (DCM). Despite the autosomal-dominant inheritance of LMNA DCM, gene-targeted mouse models of LMNA DCM show ...
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Beckermann, Thomas Martin (2014-06-26)Department: PharmacologyThe goal of this project is to better understand the relationship between cardiac sodium channel dysfunction and cardiomyopathy. Mutations in the gene SCN5A, encoding the cardiac sodium channel, typically cause ventricular ...
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Shuey, Megan Marie (2018-05-17)Department: PharmacologyPatients with resistant hypertension have uncontrolled blood pressure despite concurrent treatment with three or more antihypertensive medications including a thiazide diuretic. Compared to patients with controlled ...
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Thiel, William Howard (2008-12-02)Department: PharmacologyCa2+ activated signaling pathways coordinate contraction in the heart, but these pathways cause disease upon excessive activation. Intracellular Ca2+ activates the multifunctional Ca2+ and calmodulin dependent protein ...
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Chopra, Sameer (2008-12-06)Department: PharmacologyElectrical signaling events are required for each human thought, feeling, and perception, the movement of our limbs, and the beat of our hearts. As the initiators of action potentials in excitable tissues, voltage-gated ...
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Jeff, Janina Maria (2012-03-07)Department: Human GeneticsCardiovascular disease (CVD) is the leading cause of death in most developed countries. In addition to environmental risk factors, such as diet and physical activity, genetic risk factors contribute to the CVD risk. Risk ...