Browsing by Subject "ATAC-seq"
Now showing items 1-3 of 3
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(2020-06-11)Department: BiochemistryCurrent models of enhancer dynamics only weakly describe a role for DNA methylation within the ordered process of cellular differentiation and enhancer activation, both frequently perturbed in human disease. However, DNA ...
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Mechanism of Transcriptional control of oncogenic transcription factor fusions in tumor development (2022-06-16)Department: BiochemistryGene expression networks are perturbed in every human malignancy. One common way that this occurs is through chromosomal translocation, such as t(8;21) or t(2;13), which fuse parts of two transcription factors to create a ...
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(BMC Medica Genomics, 2020-03-06)Background Few somatic mutations have been linked to breast cancer metastasis, whereas transcriptomic differences among primary tumors correlate with incidence of metastasis, especially to the lungs and brain. However, the ...