Browsing by Subject "ATM"

Now showing items 1-3 of 3

    • A Manganese-Handling Deficit in Huntington’s Disease Selectively Impairs ATM-p53 Signaling 
      Tidball, Andrew Martin (2014-09-29)
      Department: Neuroscience
      The essential micronutrient manganese is enriched in brain, especially the basal ganglia. We sought to identify neuronal signaling pathways responsive to neurologically relevant manganese levels, as previous data suggested ...
    • DNA Damage Signaling Orchestrates SV40 Chromatin Replication 
      Sowd, Gregory Alan (2013-09-06)
      Department: Biological Sciences
      The effects of DNA damage signaling on the DNA replication of the polyomavirus SV40 are examined in this dissertation. Infection of monkey cells with SV40 results in large amounts of cellular DNA damage signaling through ...
    • Phospho-regulation of the DNA Damage Response Kinase ATR 
      Nam, Edward Adam (2011-09-07)
      Department: Cancer Biology
      Understanding how cells maintain genome integrity is necessary to gain insight into the pathology of cancer and to identify therapeutic targets and biomarkers. The DNA damage response kinase ATR is essential for the ...