Browsing by Subject "Alzheimers disease"
Now showing items 1-3 of 3
-
(2017-09-26)Department: NeuroscienceSubclinical ascorbate deficiency is widespread in many populations, but its role in both Alzheimer’s disease and normal aging is understudied. We decreased brain ascorbate in the APPSWE/PSEN1deltaE9 mouse model of Alzheimer’s ...
-
(2012-12-01)Department: PharmacologyStudies described in this thesis identify a novel mechanism for α4’s regulation of PP2Ac stability. α4 binds the PP2A catalytic subunit (PP2Ac) and the microtubule-associated E3 ubiquitin ligase MID1, and through unknown ...
-
(2018-08-03)Department: PharmacologyAmyloid precursor protein (APP) is a type I transmembrane protein and has been studied extensively due to its relevance to Alzheimer’s disease. However, its subcellular distribution and the mechanisms that regulate its ...