Browsing by Subject "BMPR2"

Now showing items 1-4 of 4

    • Bone Morphogenetic Protein Receptor Mutation and Heritable Pulmonary Arterial Hypertension 
      Frump, Andrea Lee (2014-02-11)
      Department: Cell and Developmental Biology
      More than 200 heterozygous mutations in the type 2 BMP receptor gene, BMPR2, have been identified in patients with Heritable Pulmonary Arterial Hypertension (HPAH). Two recent studies have grouped patients with BMPR2 ...
    • Low-grade albuminuria in pulmonary arterial hypertension 
      Nickel, Nils P.; Fessel, Joshua P.; Cogan, Joy D.; Hamid, Rizwam; West, James D.; de Caestecker, Mark P.; Austin, Eric D. (PULMONARY CIRCULATION, 2019-06)
      Low-grade albuminuria, determined by the urinary albumin to creatinine ratio, has been linked to systemic vascular dysfunction and is associated with cardiovascular mortality. Pulmonary arterial hypertension is related to ...
    • Src Kinase Activation in Pulmonary Arterial Hypertension 
      Prewitt, Allison Renee (2015-07-07)
      Department: Cell and Developmental Biology
      Heritable Pulmonary Arterial Hypertension (HPAH) is a rare, fatal disease of the pulmonary vasculature for which there is no cure. The majority of HPAH patients inherit mutations in the BMP type 2-receptor gene, BMPR2, but ...
    • Targeting Cellular and Molecular Mediators of Pathologic Biomechanical Remodeling in Pulmonary Arterial Hypertension 
      Bloodworth, Nathaniel Craig (2017-06-28)
      Department: Biomedical Engineering
      Pulmonary arterial hypertension (PAH) is a deadly, insidious illness of the pulmonary vasculature with no effective treatment. Until the mechanisms that drive disease progression and small vessel remodeling are better ...