Browsing by Subject "Breast Cancer"
Now showing items 1-6 of 6
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(Springer, 2012-12)As systemic cancer therapies improve and are able to control metastatic disease outside the central nervous system, the brain is increasingly the first site of relapse. The blood–brain barrier (BBB) represents a major ...
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(2019-03-12)Department: Biomedical EngineeringThere are no reliable methods to determine how an individual breast or pancreatic cancer patient will respond to a particular treatment option. Patient-derived tumor organoids offer the ability to screen drugs directly on ...
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(2013-10-11)Department: Cancer BiologyDissertation under the direction of Professor Harold L. Moses Transforming Growth Factor Beta (TGF-β) is acts as both a tumor suppressor and promoter in the context of epithelial tumor progression. In epithelial cells, ...
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(2011-04-18)Department: Cancer BiologyEph receptor tyrosine kinases are membrane bound receptors often expressed by normal epithelial cells but are frequently overexpressed in many human cancers. Of the many Eph receptors, EphA2 is present at low levels in ...
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(2017-03-27)Department: Biomedical EngineeringIn theory, siRNAs can inhibit every known cancer-causing gene through sequence-specific RNA interference. However, almost twenty years after the discovery of RNA interference, the use of siRNAs as targeted molecular medicines ...
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(2008-08-25)Department: Cancer BiologyThe EphA2 receptor belongs to the recently cloned Eph family of receptor tyrosine kinase (RTK). High levels of EphA2 RTK have been detected in 60-90% of human breast cancer specimens, both in breast cancer cells and in ...