Browsing by Subject "CRISPR"

Now showing items 1-5 of 5

    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      Lupashin, Vladimir V.); D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina D. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina; Lupashin, Vladimir V. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Defects in COG-Mediated Golgi Trafficking Alter Endo-Lysosoma System in Human Cells 
      D'Souza, Zinia; Blackburn, Jessica Bailey; Kudlyk, Tetyana; Pokrovskaya, Irina D.; Lupashin, Vladimir V. (FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2019-07-03)
      The conserved oligomeric complex (COG) is a multi-subunit vesicle tethering complex that functions in retrograde trafficking at the Golgi. We have previously demonstrated that the formation of enlarged endo-lysosomal ...
    • Delivery of CRISPR/Cas9 Ribonucleoprotein using Carrier-Free Protein Engineering or Porous Silicon Nanoparticles 
      Fletcher, Ronald Brock; 0000-0002-3986-9040 (2023-07-14)
      Department: Biomedical Engineering
      Gene editing unlocks the source code of life—DNA—for human engineering. This could enable treating myriad diseases, with huge academic and industrial efforts ongoing towards treatments for numerous cancers, neurodegenerative ...
    • Lysophospholipases as Mediators of Bioactive Lipid Metabolism and Signaling 
      Wepy, James Anthony (2019-01-02)
      Department: Chemistry
      Lysophospholipase enzymes, lysophospholipase A1 (LYPLA1) and lysophospholipase A2 (LYPLA2), are serine hydrolases responsible for the metabolism of three separate classes of bioactive lipid substrates, including ...