Browsing by Subject "Cyclooxygenases -- Inhibitors"
Now showing items 1-2 of 2
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(2008-04-18)Department: ChemistryThe cyclooxygenase (COX) enzyme catalyzes the bis-dioxygenation and cyclization of arachidonic acid to form prostaglandin H2, the common precursor of bioactive prostaglandins. The genome codes two 60% sequence-identical ...
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(2008-12-31)Department: ChemistryIndomethacin (INDO) has been a commercially available non-steroidal anti-inflammatory drug since 1963. As such, INDO has well-defined toxicology and pharmacokinetics that allow it to serve as a known molecular scaffold ...