Browsing by Subject "DNA cleavage"
Now showing items 1-2 of 2
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(2019-01-18)Department: BiochemistryType II topoisomerases are enzymes that transiently cut the DNA to regulate supercoiling and remove knots and tangles from the genome. Although they are essential for cell survivability, these enzymes are potentially ...
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(2009-02-04)Department: BiochemistryThe work presented in this dissertation examines the DNA cleavage activity of human topoisomerase II. Type II topoisomerases are required for removing DNA knots and tangles and are important chemotherapy drug targets. The ...