Browsing by Subject "DNA damage response"
Now showing items 1-10 of 10
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(2021-02-12)Department: BiochemistryHuman cells are constantly exposed to endogenous and exogenous sources of DNA damage that cause thousands of DNA lesions in each cell every day. Accurate repair of these lesions ensures maintenance of genome stability and ...
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(2006-08-09)Department: Microbiology and ImmunologyMICROBIOLOGY AND IMMUNOLOGY CHARACTERIZATION OF AN AUTOIMMUNE GENE EXPRESSION SIGNATURE KEVIN MAAS Dissertation under the direction of Professor Thomas Aune Autoimmune diseases affect approximately 5% of the human ...
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(2014-08-15)Department: PathologyThe oncogenes Mdm2 and Mdmx are often overexpressed in many human cancers. In addition to being negative regulators of the tumor suppressor p53, there is evidence these proteins have important p53-independent functions ...
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(2007-10-03)Department: Biological SciencesDNA damaging agents have been shown to stimulate the localization of human DNA helicase B (HDHB) in nuclear foci, suggesting that HDHB might participate in DNA damage response. In the first part of this dissertation, we ...
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(2012-06-15)Department: BiochemistryIn this dissertation I identify and define SWI/SNF, matrix-associated, actin-dependent regulator of chromatin, A-like 1 (SMARCAL1) as a genome maintenance protein. First, I introduce a functional genomic screen designed ...
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(2009-05-28)Department: BiochemistryGenetic instability is a hallmark of cancer. The ATR-ATRIP complex functions at the apex of a cell cycle checkpoint signaling pathway that is critical during every cell division cycle to maintain genome integrity. ATR ...
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(2014-04-17)Department: BiochemistryErrors during DNA replication lead to mutations which contribute to cancer development. To deal with these challenges, cells contain an innate machinery known as the replication stress response. ATR is the master regulator ...
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(2016-07-15)Department: BiochemistryEvery cell divisions cycle, over 6.8 billion base pairs of DNA must be accurately replicated. To further complicate this process, the DNA is damaged at a rate of ~10,000 lesions per cell per day. To overcome these obstacles, ...
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(2017-11-08)Department: BiochemistryDNA replication is constantly challenged by several sources of replication stress that can affect the accuracy and timely completion of this essential biological process. The DNA damage response (DDR) exists to address ...
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(2018-07-26)Department: PathologyGenome maintenance is essential for the viability of eukaryotic cells and for the prevention of tumorigenesis. DNA replication stress is a significant contributor to genomic instability. As such, cells employ a complex ...