Browsing by Subject "DNA topology"
Now showing items 1-4 of 4
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Effects of DNA Geometry and Topoisomerase II Poisons on Human and Bacterial Type II Topoisomerases (2017-03-15)Department: BiochemistryThe topological state of DNA has a dramatic effect on nucleic acid processes in cells. Type II topoisomerases are necessary enzymes that help regulate the topological state of the genome, but their activity requires the ...
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(2015-03-13)Department: BiochemistryCoordination between the N-terminal gate and the catalytic core of topoisomerase II allows the proper capture, cleavage, and transport of DNA during catalysis. Because the activities of these domains are tightly linked, ...
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(2013-04-15)Department: Chemical and Physical BiologyThe topological structure of DNA is regulated by ubiquitous enzymes called topoisomerases. Type II topoisomerases resolve supercoils and remove knots and tangles from the genetic material by generating transient breaks in ...
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(2009-02-04)Department: BiochemistryThe work presented in this dissertation examines the DNA cleavage activity of human topoisomerase II. Type II topoisomerases are required for removing DNA knots and tangles and are important chemotherapy drug targets. The ...