Browsing by Subject "EGFR"
Now showing items 1-11 of 11
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(2014-09-11)Department: Cancer BiologyLung cancer is the leading cause of cancer-related death in the United States and worldwide. Lung cancers that are driven by mutations in the Epidermal Growth Factor Receptor (EGFR) are treated with targeted anti-EGFR ...
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(2017-04-12)Department: Cancer BiologyLung cancer is the leading cause of cancer deaths worldwide. More than 40% of lung cancers are classified as lung adenocarcinoma (LUAD), which is defined by pathological characteristics. Oncogenic mutations in the epidermal ...
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(2006-04-20)Department: Cell and Developmental BiologyThe lining of the gastrointestinal tract, a single layer of epithelial cells, forms a dynamic barrier that protects the organism from harmful substances present in the lumen. Maintenance of a healthy gastrointestinal tract ...
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(2022-06-15)Department: Chemical & Physical BiologyCheminformatics and computer-aided drug design (CADD) have matured substantially in the last decade. CADD is no longer the niche approach of a subset of specialists, but rather an integral component of the drug discovery ...
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(2017-03-21)Department: Microbiology and ImmunologyMacrophages represent a dynamic and plastic subset of the innate immune system. Macrophage functions include immune surveillance and clearance of pathogens, but they have also been implicated in tumorigenesis. Macrophage ...
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(Cellular and Molecular Gastroenterology and Hepatology, 2019)BACKGROUND & AIMS: Pancreatitis is a major cause of morbidity and mortality and is a risk factor for pancreatic tumorigenesis. Upon tissue damage, an inflammatory response, made up largely of macrophages, provides multiple ...
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(2015-07-23)Department: Cancer BiologyEGFR-mutant lung cancers are highly sensitive to EGFR tyrosine kinase inhibitors (TKIs; erlotinib/gefitinib/afatinib), but tumors develop drug resistance within 9-16 months. Resistance to gefitinib/erlotinib commonly occurs ...
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(2012-01-25)Department: BiochemistryAnalysis of cellular signaling networks typically involves targeted measurements of phosphorylated protein intermediates. However, phosphoproteomic analyses usually require affinity enrichment of phosphopeptides and ...
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(2013-07-29)Department: Cell and Developmental BiologyMy study of three signaling pathways in the context of three gastrointestinal diseases is presented here. Firstly, the epidermal growth factor receptor (EGFR) pathway and its role in the pathogenesis of the hypertrophic ...
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(2015-03-24)Department: Cancer BiologyLung cancer remains the leading cause of cancer related deaths in the United States despite a significant number of advancements in the molecular diagnosis and treatment of this disease. Recent genome wide expression ...
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(2011-07-29)Department: Cell and Developmental BiologyEpithelial cells establish apical and basolateral (BL) membranes with distinct protein and lipid compositions. To achieve this spatial asymmetry, the cell utilizes a variety of mechanisms for differential sorting, delivery ...