Browsing by Subject "atherosclerosis"
Now showing items 1-13 of 13
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(International Journal of Moledular Sciences, 2019-06-01)The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
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(International Journal of Molecular Sciences, 2019-06-01)The PI3K/Akt pathway plays a crucial role in the survival, proliferation, and migration of macrophages, which may impact the development of atherosclerosis. Changes in Akt isoforms or modulation of the Akt activity levels ...
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(2011-05-03)Department: PathologyInvariant natural killer T (iNKT) cells are a specialized subset of immune regulatory cells that recognize glycolipid antigens and are thought to be pro-atherogenic under hyperlipidemic conditions. We previously reported ...
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(JRSM Cardiovascular Disease, 2020-02)Purpose Chronic thromboembolic pulmonary hypertension is characterized by incomplete thrombus resolution following acute pulmonary embolism, leading to pulmonary hypertension and right ventricular dysfunction. Conditions ...
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(2015-03-18)Department: PathologyAtherosclerosis is the driving force behind cardiovascular disease, the principal cause of death in the world today. To complement currently available interventions, such as statins which reduce risk of a major cardiac ...
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(2023-09-22)Department: Molecular Pathology & ImmunologyAtherosclerosis is an immune mediated hyperinflammatory disease driven by the retention and oxidation of low-density lipoprotein (LDL) in the vessel wall. The goal of this work was to determine how oxidized LDL (oxLDL) ...
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(2017-08-14)Department: Microbiology and ImmunologyOxidized low-density lipoprotein (oxLDL) is known to activate inflammatory responses in a variety of cells, especially macrophages and dendritic cells. Much of the oxLDL in circulation is complexed to antibodies, and these ...
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(2014-04-07)Department: Biomedical EngineeringPeripheral artery disease (PAD) is characterized by platelet activation and aggregation on arterial walls, resulting in vessel occlusion and ischemia. To treat PAD, it is desirable to have a high degree of angiogenesis to ...
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(2009-04-02)Department: PathologyAtherosclerosis is a chronic vascular disease which is the underlying cause of over half the deaths in the United States each year. Variations in local vascular hemodynamics predispose select sites in the vasculature to ...
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(2009-07-28)Department: PathologyMacrophage foam cells are prominent in atherosclerotic lesions. In late stage disease, much of the cholesterol accumulation within foam cells is found in large, swollen, lysosomes. Tissue culture models using human macrophages ...
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(2005-01-07)Department: PathologyThe development of atherosclerosis can be influenced by genetic or pharmacologic disruptions of cellular cholesterol homeostasis. Cholesterol homeostasis in macrophages is of critical importance because these cells have a ...
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(2010-07-12)Department: Cell and Developmental BiologyAlthough it is known that the response of endothelial cells to atherogenic disturbed flow is distinct from that elicited by non-atherogenic laminar flow, the mechanisms involved are poorly understood. Observing that ...
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(2012-03-31)Department: PathologyPatients with the autoimmune disease systemic lupus erythematosus (SLE) have an increased risk of developing premature cardiovascular disease, most notably atherosclerosis. While the mechanisms behind this increased risk ...