Browsing by Subject "autophagy"

Now showing items 1-6 of 6

    • C/EBPbeta3 (LIP) induces cell death in breast cancer cells. 
      Abreu, Maria Mercedes (2012-05-03)
      Department: Cancer Biology
      C/EBPbeta is a member of a family of basic-leucine zipper transcription factors. It has been shown to be a key regulator of growth and differentiation in the mammary gland. There are three different protein isoforms of ...
    • Elucidating the role of manganese-induced IGF signaling and autophagy in Huntington’s disease 
      Bryan, Miles Richard (2019-12-04)
      Department: Neuroscience
      Manganese is an essential micronutrient, required for the activity of many enzymes. Our lab has established that cellular and mouse models of Huntington’s Disease (HD) exhibit reduced striatal Mn bioavailability. This ...
    • Identification and Characterization of p53 Target Genes 
      Eby, Kathryn Grace (2010-06-16)
      Department: Biochemistry
      After 30 years of research, p53 is recognized as one of the most frequently mutated genes in human cancer (Baker et al, 1989; Nigro et al, 1989; Momand et al, 2000; Daujat et la, 2001). To accomplish its tumor suppressive ...
    • Insights into the Molecular Mechanisms of Phospholipase D-Mediated Cancer Cell Survival 
      Bruntz, Ronald Chase (2014-02-11)
      Department: Pharmacology
      The production of bioactive lipids by phospholipases has long been appreciated as an important mode of cellular communication. Phospholipase D (PLD) enzymes hydrolyze phosphatidylcholine to generate a choline headgroup and ...
    • Role of Autophagy in BCL-2/BCL-XL Mediated G0 Arrest 
      Valentin-Santiago, Mayda (2007-04-14)
      Department: Cancer Biology
      Although many studies have investigated the pro- and anti-apoptotic functions of the Bcl-2 family of proteins, it has been found that the anti-apoptotic Bcl-2 and Bcl-xL molecules also have a role in the cell cycle. It has ...
    • The Role of Tepsin in Membrane Trafficking and Autophagy 
      Wallace, Natalie Serina; 0000-0002-9409-2721 (2023-03-14)
      Department: Biological Sciences
      Adaptor Protein 4 (AP-4) vesicles originating at the trans-Golgi network (TGN) target delivery of ATG9A, a scramblase essential for autophagosome biogenesis, to the cell periphery. AP-4 loss causes hereditary spastic ...