Browsing by Subject "beta cell"

Now showing items 1-5 of 5

    • Dissecting Pancreatic β-cell Stress Using Whole Transcriptome Sequencing 
      Stancill, Jennifer Susan (2017-03-29)
      Department: Cell and Developmental Biology
      Type 2 diabetes is characterized by failure of pancreatic β-cells to secrete adequate insulin to meet the needs of the body. This β-cell failure is thought to be caused by increased metabolic load due to mounting insulin ...
    • Modeling mammalian metabolism using novel stable isotopic techniques 
      Rahim, Mohsin; 0000-0001-8407-5621 (2021-08-16)
      Department: Chemical Engineering
      Biochemical methods to quantify gene transcript, enzyme, and metabolite levels are widely used to assess metabolic pathway regulation. Though informative and even vital in some contexts, static measurements of biomolecule ...
    • Ngn3-expressing progenitor heterogeneity drives endocrine lineage allocation in pancreas development 
      Liu, Jing (2015-11-17)
      Department: Cell and Developmental Biology
      Diabetes is a worldwide health issue. In both type I and late stage type II diabetes, significant beta-cell loss causes insulin deficiency and hyperglycemia. Replenishing beta cells is a promising therapy and it requires ...
    • Regulated Glucagon Secretion from Islet and Pseudo-Islet Alpha Cells 
      Reissaus, Christopher Alan (2017-04-07)
      Department: Molecular Physiology and Biophysics
      Misregulated hormone secretion from the islets of Langerhans is central to the pathophysiology of Diabetes. While insulin plays a key role in glucose regulation and the modulation of secretion has immediate clinical ...
    • The Role of FoxM1 in Pancreatic Beta Cell Mass Regeneration and Expansion 
      Misfeldt, Amanda Ackermann (2008-09-29)
      Department: Molecular Physiology and Biophysics
      MOLECULAR PHYSIOLOGY AND BIOPHYSICS THE ROLE OF FOXM1 IN PANCREATIC BETA CELL MASS REGENERATION AND EXPANSION AMANDA ACKERMANN MISFELDT Dissertation under the direction of Maureen Gannon, Ph.D. The size of an organism’s ...